1032418-30-6Relevant articles and documents
Synthesis, and in vitro antitumor activity of a new series of 4-chloro-2-mercapto-5-methylbenzenesulfonamide derivatives
Slawinski,Brzozowski
, p. 1433 - 1440 (2008/09/18)
The synthesis of S-(5-chloro-4-methyl-2-sulfamoylphenyl) N-(phenylsulfonyl)benzo-thiohydrazonates 4a-k is described. The compounds 4b-fand 4j-k were screened at the US National Cancer Institute for their in vitro activities against a panel of 53-57 human tumor cell lines and relationship between structure and antitumor activity is discussed. The compound 4b was inactive, whereas the remaining compounds exhibited fairly high or reasonable activity (GI50 = 8.12-24.9 μM) against one or more human tumor cell lines.