1032422-60-8

Basic information

• Product Name: C₂₀H₂₁ClN₂O₅S
• Synonyms: C₂₀H₂₁ClN₂O₅S
• CAS NO: 1032422-60-8
• Molecular Weight: 436.916
• Mol File: 1032422-60-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₁ClN₂O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₁ClN₂O₅S(1032422-60-8)
• EPA Substance Registry System: C₂₀H₂₁ClN₂O₅S(1032422-60-8)

Safety Data

• Hazardous Substances Data: 1032422-60-8(Hazardous Substances Data)

Upstream product

• 346718-87-4 4-chloro-N-(4-iodophenyl)benzene-1-sulfonamide 

Downstream Products

• 1032422-49-3 C₁₈H₁₉ClN₂O₄S 

Relevant articles and documents

HDAC INHIBITORS

The use of compounds of the formula (I): Ar1-L1-Ar2-L2-C(R3)(R4)N(OR1)C(=Y)-R2 where Y is selected from O or S; R1 is H, a salt or readily hydrolysable substituent; R2 is selected from H or CH3, CH2F, CF2H or CF3; R3 and R4 are selected independently from H, C1-4 alkyl or alkenyl, CF3, CH2F, CF2H and F, with the proviso that if either R3 or R4 is H, then the other is not H; L1 is a linker group; L2 is a linker group comprising an optionally substituted or unsubstituted unsaturated branched or straight chain alkyl group; Ar1 is an optionally substituted or unsubstituted aryl or heterocyclic group; and Ar2 is an optionally substituted or unsubstituted aryl or heterocyclic group, in the treatment of HDAC mediated diseases or diseases provide improved therapies due to the potent inhibition of HDAC and long duration of activity in vivo after oral administration. They are potential useful in diseases in which HDAC has been implicated, e.g. psoriasis, cancer, Alzheimer's disease, Huntington's disease and HIV.