103259-38-7

Basic information

• Product Name: (3,5-Dimethyl-phenyl)-(5,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-4-yl)-amine
• CAS NO: 103259-38-7
• Molecular Weight: 292.384
• Mol File: 103259-38-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3,5-Dimethyl-phenyl)-(5,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-4-yl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-Dimethyl-phenyl)-(5,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-4-yl)-amine(103259-38-7)
• EPA Substance Registry System: (3,5-Dimethyl-phenyl)-(5,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-4-yl)-amine(103259-38-7)

Safety Data

• Hazardous Substances Data: 103259-38-7(Hazardous Substances Data)

Upstream product

• 85518-76-9 3,5-dimethylphenylamine hydrochloride 
• 108-94-1 cyclohexanone 
• 1260243-04-6 ethyl 5-amino-1H-pyrazole-4-carboxylate 

Downstream Products

• 103303-92-0 (3,5-Dimethyl-phenyl)-(1-morpholin-4-ylmethyl-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-4-yl)-amine 
• 103259-47-8 (3,5-Dimethyl-phenyl)-(1-piperidin-1-ylmethyl-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-4-yl)-amine 

Relevant articles and documents

Phosphorus Pentoxide in Organic Synthesis, XXIX. - Synthesis of 4-Arylamino-5,6,7,8-tetrahydro-1H-pyrazoloquinolines and the Corresponding N-Mannich Bases

4-Arylamino-5,6,7,8-tetrahydro-1H-pyrazoloquinolines 2 have been synthesized from ethyl 5-amino-1H-pyrazole-4-carboxylate (1) and cyclohexanone by heating in a reagent mixture of P4O10, N,N-dimethylcyclohexylamine, and an appropriate arylamine hydrochloride (8-52percent yield).Reaction of 2 with formaldehyde and secondary amines afforded the Mannich bases 3 in 45-94percent yield.Attempts to prepare the 5,6,7,8-dehydrogenated analogues of 2 using a previously adopted method failed.