103286-06-2

Basic information

• Product Name: 7-nitro-2-phenyl-1(2H)-phthalazinone
• Synonyms: 7-nitro-2-phenyl-1(2H)-phthalazinone
• CAS NO: 103286-06-2
• Molecular Weight: 267.244
• Mol File: 103286-06-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-nitro-2-phenyl-1(2H)-phthalazinone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-nitro-2-phenyl-1(2H)-phthalazinone(103286-06-2)
• EPA Substance Registry System: 7-nitro-2-phenyl-1(2H)-phthalazinone(103286-06-2)

Safety Data

• Hazardous Substances Data: 103286-06-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 64-19-7 acetic acid 
• 87-41-2 2-benzofuran-1(3H)-one 
• 89891-73-6 6-nitro-3-bromo-3H-isobenzofuran-1-one 
• 59-88-1 phenylhydrazine hydrochloride 
• 85-44-9 phthalic anhydride 
• 7464-91-7 2-formyl-5-nitrobenzoic acid 
• 5466-84-2 4-nitrophthalic anhydride 
• 610-93-5 6-nitrophthalide 
• 77619-93-3 3-hydroxy-6-nitro-1-(3H)isobenzofuranone 

Downstream Products

• 103286-35-7 2-phenyl-1(2H)-phthalazinone 7-dimethylamino N-oxide 
• 103286-48-2 7-dimethylamino-2-phenyl-1(2H)-phthalazinone 
• 103286-34-6 7-amino-2-phenyl-1(2H)-phthalazinone 

Relevant articles and documents

Synthesis and Investigation of Phthalazinones as Antitubercular Agents

A series of 2- and 7-substituted phthalazinones was synthesised and their potential as anti-tubercular drugs assessed via Mycobacterium tuberculosis (mc26230) growth inhibition assays. All phthalazinones tested showed growth inhibitory activity (MIC 100 μm), and those compounds containing lipophilic and electron-withdrawing groups generally exhibited better anti-tubercular activity. Several lead compounds were identified, including 7-((2-amino-6-(4-fluorophenyl)pyrimidin-4-yl)amino)-2-heptylphthalazin-1(2H)-one (MIC=1.6 μm), 4-tertbutylphthalazin-2(1H)-one (MIC=3 μm), and 7-nitro-phthalazin-1(2H)-one (MIC=3 μm). Mode of action studies indicated that selected pyrimidinyl-phthalazinones may interfere with NADH oxidation, however, the mode of action of the lead compound is independent of this enzyme. MIC=minimum inhibitory concentration.