103286-27-7

Basic information

• Product Name: 1-(2-bromo-4-methylphenyl)ethanone
• Synonyms: 1-(2-bromo-4-methylphenyl)ethanone
• CAS NO: 103286-27-7
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.07116
• Mol File: 103286-27-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 134-136℃ (15 Torr)
• Appearance: /
• Density: 1.388±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(2-bromo-4-methylphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-4-methylphenyl)ethanone(103286-27-7)
• EPA Substance Registry System: 1-(2-bromo-4-methylphenyl)ethanone(103286-27-7)

Safety Data

• Hazardous Substances Data: 103286-27-7(Hazardous Substances Data)

Usage

General Description

1-(2-bromo-4-methylphenyl)ethanone, also known as 2-Bromo-1-(4-methylphenyl)ethanone, is a chemical compound categorized as an organic compound. The molecular formula is C9H9BrO. The compound includes elements such as carbon (C), hydrogen (H), bromine (Br), and oxygen (O). The structure of the compound incorporates a bromo group and a methyl group, attached to phenyl and ethanone moieties, which are all bound together via covalent bonds. It's often used as a reactant or intermediate in organic synthesis due to its reactive nature. The presence of the ethanone group in this chemical gives it the ketone functionality. Safety measures should be taken while handling this chemical as it may cause eye and skin irritation. It should be used in a well-ventilated area to avoid inhalation.

Upstream product

• 591-17-3 meta-bromotoluene 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 53456-09-0 4-methyl-2-bromobenzoyl chloride 
• 7697-27-0 2-bromo-4-methylbenzoic acid 
• 824-54-4 2-bromo-4-methylbenzaldehyde 
• 75-16-1 methylmagnesium bromide 
• 947546-75-0 2-bromo-1-ethynyl-4-methylbenzene 

Downstream Products

• 855938-99-7 1-(4-methyl-2-phenoxy-phenyl)-ethanone 
• 24852-84-4 4-methyl-2-(methylthio)acetophenone 
• 134365-29-0 2-bromo-4-methyl-5-nitroacetophenone 
• 122-00-9 para-methylacetophenone 
• 874651-69-1 (E)-1-(2-bromo-4-methylphenyl)-3-phenylprop-2-en-1-one 
• 540493-06-9 1-(4-Methyl-2-methylsulfanyl-phenyl)-ethanone oxime 
• 134365-31-4 4-methyl-2,5-bis(methylthio)acetophenone 
• 174344-19-5 N-[3-Methyl-2-(4-methyl-benzoyl)-benzofuran-6-yl]acetamide 
• 123971-35-7 4-(4-methylphenyl)-2-thiazolecarboxylic acid 
• 131002-03-4 4-methyl-2- bromobenzamide 

Relevant articles and documents

The intramolecular reaction of acetophenoneN-tosylhydrazone and vinyl: Br?nsted acid-promoted cationic cyclization toward polysubstituted indenes

In the presence of TsNHNH2, a Br?nsted acid-promoted intramolecular cyclization ofo-(1-arylvinyl) acetophenone derivatives was developed, leading to polysubstituted indenes with complexity and diversity in moderate to excellent yields. In sharp contrast with either the radical or carbene involved cyclization of aldehydicN-tosylhydrazone with vinyl, a cationic cyclization pathway was involved, whereN-tosylhydrazone served as an electrophile and alkylation reagent during this transformation.

Atmosphere-Controlled Palladium-Catalyzed Divergent Decarboxylative Cyclization of 2-Iodobiphenyls and α-Oxocarboxylic Acids

A novel palladium-catalyzed divergent decarboxylative cyclization of 2-iodobiphenyls and α-oxocarboxylic acids utilizing the atmosphere as a controlled switch is reported. Under the protection of a nitrogen atmosphere, tribenzotropones are synthesized by a [4 + 3] decarboxylative cyclization. Employing a palladium/O2 system enables a [4 + 2] decarboxylative cyclization to assemble triphenylenes. Notably, preliminary mechanistic studies indicate that the formation of triphenylenes involves a double decarboxylation.

Catalyst- and acid-free Markovnikov hydration of alkynes in a sustainable H2O/ethyl lactate system

An efficient and sustainable protocol for the hydration of alkynes has been developed under metal/acid/catalyst/ligand-free conditions in a water/ethyl lactate mixture. The hydrogen-bond network in the ethyl lactate and water mixture plays a crucial and decisive role in activating the alkynes for hydration to afford the corresponding methyl ketones. This strategy gives the Markovnikov (ketone) addition product selectively over other possible products. The essential role of hydrogen bonding has been confirmed by experimental and theoretical techniques. A probable mechanism has been suggested by various control tests. The efficacy of the method has been further explored for the competent production of value-added α,β-unsaturated carbonyl compounds through the reaction of aldehydes with alkynes as ketonic surrogates. The environmentally benign hydration method takes place under mild conditions, has broad functional-group compatibility, and uses the ethyl lactate/water (1:3) medium as a “green alternative” in the absence of any hazardous, harmful, or expensive substances.