103300-89-6

Basic information

• Product Name: N6-Trifluoroacetyl-L-lysyl-L-proline
• Synonyms: EPSILON-TRIFLUOROACETYL-L-LYSYL-L-PROLINE;H-LYS(TFA)-PRO-OH;TFA-LYS-PRO;n6-trifluoroacetyl-l-lysyl-l-proline;N-EPSILON-TRIFLUOROACETYL-LYS-PRO;epsilon-Trifluoracetyl-L-lysyl-L-proline;1-[2-Amino-6-(2,2,2-triflour-acetylamino)-hexanoyl)]-pyrrolidin-2-carbonsure;NEPSILON-Trifluoroacetyl-L-lysyl-L-proline
• CAS NO: 103300-89-6
• Molecular Formula: C₁₃H₂₀F₃N₃O₄
• Molecular Weight: 339.31
• Product Categories: Intermediates of Sertraline
• Mol File: 103300-89-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 550.929 °C at 760 mmHg
• Flash Point: 286.992 °C
• Appearance: /
• Density: 1.364 g/cm³
• Vapor Pressure: 1.37E-13mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: −20°C
• PKA: 3.17±0.20(Predicted)
• CAS DataBase Reference: N6-Trifluoroacetyl-L-lysyl-L-proline(CAS DataBase Reference)
• NIST Chemistry Reference: N6-Trifluoroacetyl-L-lysyl-L-proline(103300-89-6)
• EPA Substance Registry System: N6-Trifluoroacetyl-L-lysyl-L-proline(103300-89-6)

Safety Data

• WGK Germany: 1
• Hazardous Substances Data: 103300-89-6(Hazardous Substances Data)

Usage

Description

N6-Trifluoroacetyl-L-lysyl-L-proline is a synthetic dipeptide derived from the combination of L-lysine and L-proline amino acids, with a trifluoroacetyl group attached to the lysine residue. This modification enhances its reactivity and stability, making it a versatile compound for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
N6-Trifluoroacetyl-L-lysyl-L-proline is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity allow for the development of new drugs with improved properties, such as enhanced bioavailability, stability, and targeted action.
Used in Chemical Synthesis:
In the field of chemical synthesis, N6-Trifluoroacetyl-L-lysyl-L-proline serves as a key building block for the creation of complex organic molecules. Its trifluoroacetyl group provides additional functional groups that can be further modified or used in the formation of novel chemical entities.
Used in Research and Development:
N6-Trifluoroacetyl-L-lysyl-L-proline is utilized as a research tool in the study of peptide chemistry, protein structure, and function. Its unique properties make it an attractive candidate for investigating the effects of modifications on peptide behavior and interactions with other biomolecules.
Used in the Preparation of Semisynthetic Dipeptides:
N6-Trifluoroacetyl-L-lysyl-L-proline is used as a starting material in the preparation and reductive condensation with oxophenylbutyrate to synthesize semisynthetic dipeptides. These semisynthetic dipeptides have potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C13H20F3N3O4/c14-13(15,16)12(23)18-6-2-1-4-8(17)10(20)19-7-3-5-9(19)11(21)22/h8-9H,1-7,17H2,(H,18,23)(H,21,22)/t8-,9-/m0/s1

Upstream product

• 112139-31-8 C₉H₁₂ClF₃N₂O₄ 
• 10009-20-8 (S)-6-trifluoroacetylamino-2-aminohexanoic acid 
• 42267-27-6 N^ε-trifluoroacetyl-L-lysine N^α-carboxanhydride 
• 147-85-3 L-proline 

Downstream Products

• 112246-14-7 N^ε-(trifluoroacetyl)-N^α-<(R)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-lysyl-L-proline 
• 103300-91-0 N^ε-(trifluoroacetyl)-N^α-<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-lysyl-L-proline 

Relevant articles and documents

Synthesis of semisynthetic dipeptides using N-carboxyanhydrides and chiral induction on Raney nickel. A method practical for large scale

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