103321-58-0

Basic information

• Product Name: FMOC-D-PHENYLALANYL CHLORIDE
• Synonyms: FMOC-D-PHENYLALANYL CHLORIDE;FMOC-D-PHE-CL;NALPHA-9-Fluorenylmethoxycarbonyl-D-phenylalanyl chloride
• CAS NO: 103321-58-0
• Molecular Formula: C₂₄H₂₀ClNO₃
• Molecular Weight: 405.87
• Product Categories: Amino Acids
• Mol File: 103321-58-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 115-117 °C
• Boiling Point: 596.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.279±0.06 g/cm3(Predicted)
• Storage Temp.: Store at 0°C
• PKA: 10.31±0.46(Predicted)
• CAS DataBase Reference: FMOC-D-PHENYLALANYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D-PHENYLALANYL CHLORIDE(103321-58-0)
• EPA Substance Registry System: FMOC-D-PHENYLALANYL CHLORIDE(103321-58-0)

Safety Data

• Hazardous Substances Data: 103321-58-0(Hazardous Substances Data)

Usage

General Description

FMOC-D-PHENYLALANYL CHLORIDE is a chemical compound that is commonly used in the field of organic chemistry. It is a derivative of phenylalanine and contains a fluorogenic protecting group, making it useful for the synthesis of peptide and protein molecules. FMOC-D-PHENYLALANYL CHLORIDE is mainly used as a reagent for the solid-phase peptide synthesis, where it serves as a blocking group for the amino group of the phenylalanine residue. FMOC-D-PHENYLALANYL CHLORIDE is also an important building block for the production of various bioactive peptides and has applications in pharmaceutical research and drug development.

Upstream product

• 86123-10-6 Fmoc-D-Phe-OH 

Downstream Products

• 594857-67-7 C₆₃H₆₇N₇O₈ 
• 252032-22-7 (1S,4S)-1,3,4,6-tetrahydro-3,6-dioxo-1-(phenylmethyl)-2H-pyrazino[2,1-b]quinazoline-4-propanamide 
• 252032-23-8 (1R,4S)-1,3,4,6-tetrahydro-3,6-dioxo-1-(phenylmethyl)-2H-pyrazino[2,1-b]quinazoline-4-propanamide 
• 227624-29-5 [1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

Eco-friendly synthesis of peptides using fmoc-amino acid chlorides as coupling agent under biphasic condition

Background: Agro-waste derived solvent media act as a greener process for the peptide bond formation using Nα-Fmoc-amino acid chloride and amino acid ester salt with in situ neutralization and coupling under biphasic condition. The Fmoc-amino acid chlorides are prepared by the reported procedure of freshly distilled SOCl2 with dry CH2Cl2. The protocol found many added ad-vantages such as neutralization of amino acid ester salt and not required additional base for the neu-tralization, and directly coupling take place with Fmoc-amino acid chloride gave final product dipeptide ester in good to excellent yields. The protocol occurs with complete stereo chemical integrity of the configuration of substrates. Here, we revisited Schotten-Baumann condition, instead of using inorganic base. Objective: To develop green protocol for the synthesis of peptide bond using Fmoc-amino acid chloride with amino acid esters salt. Methods: The final product isolated is analyzed in several spectroscopic and analytical techniques such as FT-IR,1H-,13C-NMR, Mass spectrometry and RP-HPLC to check stereo integrity and puri-ty of the product. Conclusion: The present method developed greener using natural agro-waste (lemon fruit shell ash) derived solvent medium for the reaction and not required chemical entity.

PEPTIDE ANTIBIOTICS

There is provided a range of novel compounds. These novel compounds may demonstrate a broad spectrum antibacterial and antifungal activity. These compounds may be active against the emerging polymyxin resistant bacteria. These compounds may also be useful

((9-Fluorenylmethyl)oxy)carbonyl (Fmoc) Amino Acid Chlorides. Synthesis, Characterization, and Application to the Rapid Synthesis of Short Peptide Segments

Fmoc amino acid chlorides are described as stable, easily synthesized coupling agents and shown to be useful in a novel method of rapid, repetitive peptide synthesis