1033224-87-1 Usage
Description
1-(3-Methoxyphenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide, commonly known as bendroflumethiazide, is a thiazide diuretic medication used to treat high blood pressure and swelling due to congestive heart failure. It functions by increasing the excretion of water and salt through urine, thus lowering blood pressure and reducing swelling. Bendroflumethiazide is typically administered orally, with its effects manifesting within a few hours. While generally well-tolerated, potential side effects include dizziness, muscle cramps, and low potassium levels. It is crucial to adhere to the prescribed dosage and maintain regular check-ups with a healthcare provider during treatment.
Uses
Used in Pharmaceutical Industry:
1-(3-Methoxyphenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide is used as an antihypertensive and diuretic agent for the treatment of high blood pressure and swelling due to congestive heart failure. Its application is based on its ability to increase the amount of water and salt expelled from the body through urine, which aids in lowering blood pressure and reducing swelling.
Used in Cardiology:
In the field of cardiology, bendroflumethiazide is utilized to manage conditions related to high blood pressure and congestive heart failure. Its use is justified by its effectiveness in reducing fluid retention and improving the overall cardiovascular health of patients.
Used in Nephrology:
1-(3-Methoxyphenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide is also used in nephrology to address issues related to fluid balance and electrolyte regulation in patients with kidney disorders. Its diuretic properties help in managing水肿 (edema) and maintaining proper electrolyte balance.
Check Digit Verification of cas no
The CAS Registry Mumber 1033224-87-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,3,2,2 and 4 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1033224-87:
(9*1)+(8*0)+(7*3)+(6*3)+(5*2)+(4*2)+(3*4)+(2*8)+(1*7)=101
101 % 10 = 1
So 1033224-87-1 is a valid CAS Registry Number.
1033224-87-1Relevant articles and documents
Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-Aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3 H)-yl]-1-(methylamino)butan-2- ols (WYE-103231)
O'Neill, David J.,Adedoyin, Adedayo,Alfinito, Peter D.,Bray, Jenifer A.,Cosmi, Scott,Deecher, Darlene C.,Fensome, Andrew,Harrison, Jim,Leventhal, Liza,Mann, Charles,McComas, Casey C.,Sullivan, Nicole R.,Spangler, Taylor B.,Uveges, Albert J.,Trybulski, Eugene J.,Whiteside, Garth T.,Zhang, Puwen
experimental part, p. 4511 - 4521 (2010/08/20)
Structural modification of a virtual screening hit led to the identification of a new series of 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol- 1(3H)-yl]-1-(methylamino)butan-2-ols which are potent and selective inhibitors of the norepinephrine transporter over both the serotonin and dopamine transporters. One representative compound S-17b (WYE-103231) had low nanomolar hNET potency (IC50 = 1.2 nM) and excellent selectivity for hNET over hSERT (>1600-fold) and hDAT (>600-fold). S-17b additionally had a good pharmacokinetic profile and demonstrated oral efficacy in rat models of ovariectomized-induced thermoregulatory dysfunction and morphine dependent flush as well as the hot plate and spinal nerve ligation (SNL) models of acute and neuropathic pain.
