1033553-70-6

Basic information

• Product Name: 4-hydroxy-6-(4-methoxy-phenyl)-4-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester
• CAS NO: 1033553-70-6
• Molecular Weight: 308.334
• Mol File: 1033553-70-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-hydroxy-6-(4-methoxy-phenyl)-4-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-6-(4-methoxy-phenyl)-4-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester(1033553-70-6)
• EPA Substance Registry System: 4-hydroxy-6-(4-methoxy-phenyl)-4-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester(1033553-70-6)

Safety Data

• Hazardous Substances Data: 1033553-70-6(Hazardous Substances Data)

Upstream product

• 52287-67-9 N-[(4-methoxyphenyl)(tosyl)methyl]urea 
• 141-97-9 ethyl acetoacetate 
• 867372-91-6 2-[(4-methoxy-phenyl)-phenoxycarbonylamino-methyl]-3-oxo-butyric acid ethyl ester 
• 123-11-5 4-methoxy-benzaldehyde 
• 867372-86-9 phenyl [(p-metoxyphenyl)(tosyl)methyl]carbamate 

Downstream Products

• 161374-07-8 ethyl 4-(4-methoxyphenyl)-6-methyl-1,2,3,4-tetrahydropyrimidin-2-one-5-carboxylate 

Relevant articles and documents

Towards Enzyme-like, Sustainable Catalysis: Switchable, Highly Efficient Asymmetric Synthesis of Enantiopure Biginelli Dihydropyrimidinones or Hexahydropyrimidinones

Organocatalysts displaying a network of cooperative hydrogen bonds (NCHB) have been employed in an enzyme-like manner for a direct, switchable synthesis of enantiopure hexahydropyrimidinones (HHPMs) or dihydropyrimidinones (DHPMs), which starts at a common, easily accessible α-ureidosulfone stage. The NCHB organocatalyst exploits all its potential as a pure hydrogen-bond biomimetic catalyst even in the presence of organic bases. This one-pot, diastereo- and enantioselective synthetic procedure has been proven to be robust, scalable, highly efficient, and environmentally benign. A straightforward and truly practical entry to enantiopure HHPMs is reported for the first time.