1033619-94-1

Basic information

• Product Name: (2-chloro-thiazol-5-ylmethyl)-(4-fluorophenyl)-carbamic acid tert-butyl ester
• Synonyms: (2-chloro-thiazol-5-ylmethyl)-(4-fluorophenyl)-carbamic acid tert-butyl ester
• CAS NO: 1033619-94-1
• Molecular Weight: 342.822
• Mol File: 1033619-94-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2-chloro-thiazol-5-ylmethyl)-(4-fluorophenyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chloro-thiazol-5-ylmethyl)-(4-fluorophenyl)-carbamic acid tert-butyl ester(1033619-94-1)
• EPA Substance Registry System: (2-chloro-thiazol-5-ylmethyl)-(4-fluorophenyl)-carbamic acid tert-butyl ester(1033619-94-1)

Safety Data

• Hazardous Substances Data: 1033619-94-1(Hazardous Substances Data)

Upstream product

• 60144-53-8 N-(tert-butoxycarbonyl)-4-fluoroaniline 
• 105827-91-6 α-Cl-β-thiazolyl chloride 

Downstream Products

• 1033619-95-2 (4-fluorophenyl)-(2-piperidin-1-yl-thiazol-5-ylmethyl)-carbamic acid tert-butyl ester 
• 1034136-28-1 4-fluorophenyl-2-pyrrolidin-1-ylthiazol-5-ylmethyl carbamic acid tert-butyl ester 

Relevant articles and documents

ION CHANNEL MODULATORS

The present teachings provide carboxylic amide compounds that can modulate the activity of ion channels in a mammal. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.

ION CHANNEL MODULATORS

The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R1', R2, R3, R4 R4', and p are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.