1033717-19-9 Usage
General Description
The chemical "1-Piperazinecarboxylic acid, 2,4-diMethyl-, 1,1-diMethylethyl ester, (2R)-" is an organic compound and a derivative of piperazinecarboxylic acid. It is also known as 2,4-dimethylpiperazine-1-carboxylic acid 1,1-dimethylethyl ester. 1-Piperazinecarboxylic acid, 2,4-diMethyl-, 1,1-diMethylethyl ester, (2R)- is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs, particularly in the production of antihistamines and antipsychotic medications. It is also used as a building block in organic synthesis and chemical research. It is important to handle this chemical with care, as it can be hazardous if not properly managed.
Check Digit Verification of cas no
The CAS Registry Mumber 1033717-19-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,3,7,1 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1033717-19:
(9*1)+(8*0)+(7*3)+(6*3)+(5*7)+(4*1)+(3*7)+(2*1)+(1*9)=119
119 % 10 = 9
So 1033717-19-9 is a valid CAS Registry Number.
1033717-19-9Relevant articles and documents
Dynamic thermodynamic resolution of lithiated N-Boc-N′- alkylpiperazines
Robinson, Steven P.,Sheikh, Nadeem S.,Baxter, Carl A.,Coldham, Iain
, p. 3642 - 3644 (2010)
Deprotonation of N-Boc-N′-alkylpiperazines with sec-BuLi in Et 2O-TMEDA gave the 2-lithio derivatives which were resolved in the presence of a chiral ligand. The best ligands for the asymmetric substitution were diamino-alkoxides that promoted a dynamic thermodynamic resolution (DTR) of the organolithium at -30 °C. Electrophilic quench gave enantiomerically enriched 2-substituted piperazines. Of a selection of piperazines, the N′-t-butyl derivative gave the best results, with the product N-Boc-N′-t-butyl-2-substituted piperazines being formed with enantiomer ratios up to 81:19.
