103373-08-6

Basic information

• Product Name: Benzofuran-2-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide
• Synonyms: Benzofuran-2-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide
• CAS NO: 103373-08-6
• Molecular Weight: 413.408
• Mol File: 103373-08-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzofuran-2-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran-2-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide(103373-08-6)
• EPA Substance Registry System: Benzofuran-2-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide(103373-08-6)

Safety Data

• Hazardous Substances Data: 103373-08-6(Hazardous Substances Data)

Upstream product

• 496-41-3 Benzofuran-2-carboxylic acid 
• 103343-84-6 (3RS)-3-amino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one 

Relevant articles and documents

Methods for Drug Discovery: Development of Potent, Selective, Orally Effecive Cholecystokinin Antagonists

3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described.Developed by reasoned modification of the known anxiolytic benzodiazepines, these compounds provide highly potent, orally effective ligands selective for peripheral (CCK-A) receptors, with binding affinities approaching or equaling that of the natural ligand CCK-8.The distinction between CCK-A receptors on the one hand and CNS (CCK-B), gastrin, and central benzodiazepine receptors on the other is demonstrated by using the structure-activity profiles of the new compounds.Details of the binding of these agents to CCK-A receptors are examined, and the method of development of these compounds is discussed in terms of its relevance to the general problem of drug discovery.