1033977-22-8Relevant articles and documents
Bis-aryl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
Aster, Susan D.,Graham, Donald W.,Kharbanda, Divya,Patel, Gool,Ponpipom, Mitree,Santorelli, Gina M.,Szymonifka, Michael J.,Mundt, Steven S.,Shah, Kashmira,Springer, Marty S.,Thieringer, Rolf,Hermanowski-Vosatka, Anne,Wright, Samuel D.,Xiao, Jianying,Zokian, Hratch,Balkovec, James M.
, p. 2799 - 2804 (2008/12/21)
3-Aryl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They are active in both in vitro and an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relatio
