1034123-64-2

Basic information

• Product Name: (S)-4-hydroxy-2-oxo-4-phenylbutanoic acid
• Synonyms: (S)-4-hydroxy-2-oxo-4-phenylbutanoic acid
• CAS NO: 1034123-64-2
• Molecular Weight: 194.187
• Mol File: 1034123-64-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-hydroxy-2-oxo-4-phenylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-hydroxy-2-oxo-4-phenylbutanoic acid(1034123-64-2)
• EPA Substance Registry System: (S)-4-hydroxy-2-oxo-4-phenylbutanoic acid(1034123-64-2)

Safety Data

• Hazardous Substances Data: 1034123-64-2(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 

Downstream Products

• 1914-59-6 (E)-2-oxo-4-phenyl-3-butenoic acid 
• 100-52-7 benzaldehyde 

Relevant articles and documents

The putative Diels-Alderase macrophomate synthase is an efficient aldolase

We find that the putative Diels-Alderase macrophomate synthase (MPS) catalyzes the addition of pyruvate enolate, generated by decarboxylation of oxaloacetate, to a variety of aldehydes. Alkyl, aryl, and heteroaryl aldehydes are accepted as substrates, providing γ-hydroxy-α-ketoacids in 35-95% yield with modest levels of stereochemical control. These aldol products, which are difficult to synthesize by other methods, are formed with efficiency comparable to that of macrophomate. Our results thus provide evidence that a two-step Michael-aldol pathway is a plausible alternative to the postulated [4 + 2] cycloaddition in the MPS-catalyzed addition of pyruvate enolate to 2-pyrones. They are also relevant to understanding the divergent evolution of type II pyruvate aldolases. Copyright