103429-31-8 Usage
Description
CTOP, with the chemical formula D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2, is a selective cyclic μ-opioid receptor antagonist. It plays a significant role in regulating behavior and expression in rats and has potential applications in the treatment of pain by improving morphine tolerance through the blocking of mTOR.
Uses
Used in Pharmaceutical Industry:
CTOP is used as a μ-opioid receptor antagonist for the treatment of pain. It enhances morphine tolerance by blocking the mTOR pathway, providing a more effective pain management strategy.
Used in Research and Development:
CTOP is used as a research tool to study the anxiogenic effects induced by the antagonist in mice and rats. This helps in understanding the role of μ-opioid receptors in anxiety and related behaviors.
Used in Veterinary Medicine:
In the veterinary field, CTOP is used to study the effect of the μ-opioid antagonist on bovine milk-derived lactoferrin (BLF)-induced analgesia. This aids in comprehending the interaction between μ-opioid receptors and other pain-relieving agents in animals.
Used in Neuroscience:
CTOP is utilized to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate behaviors generated in the elevated T-maze (ETM). This contributes to the understanding of the complex interplay between different neurotransmitter systems in the brain.
Biochem/physiol Actions
Selective ligand for μ-opioid receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 103429-31-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,4,2 and 9 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 103429-31:
(8*1)+(7*0)+(6*3)+(5*4)+(4*2)+(3*9)+(2*3)+(1*1)=88
88 % 10 = 8
So 103429-31-8 is a valid CAS Registry Number.
InChI:InChI=1/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)
103429-31-8Relevant articles and documents
Design and Synthesis of Conformationally Constrained Somatostatin Analogues with High Potency and Specificity for μ Opioid Receptors
Pelton, John T.,Kazmierski, Wieslaw,Gulya, Karoly,Yamamura, Henry I.,Hruby, Victor J.
, p. 2370 - 2375 (2007/10/02)
A series of cyclic, conformationally constrained peptides related to somatostatin were designed and synthesized in an effort to develop highly selective and potent peptides for the μ opioid receptor.The following new peptides were prepared and tested for
