103438-84-2 Usage
Description
2-Fluoro-5-hydroxybenzaldehyde is an organic compound characterized by the presence of a fluorine atom at the 2nd position and a hydroxyl group at the 5th position of a benzene ring, with an aldehyde functional group attached to the 1st position. This unique structure endows it with specific chemical properties and reactivity, making it a valuable intermediate in the synthesis of various complex organic molecules.
Uses
Used in Enantioselective Synthesis:
2-Fluoro-5-hydroxybenzaldehyde is used as a key intermediate in the enantioselective synthesis of 1,1''-spirobiindane-7,7''-diol (SPINOL) derivatives. SPINOL is a versatile chiral ligand widely employed in asymmetric catalysis, which plays a crucial role in the development of enantiomerically pure pharmaceuticals and agrochemicals. The unique properties of 2-fluoro-5-hydroxybenzaldehyde, such as its fluorine substitution and hydroxyl group, contribute to the efficient and selective formation of SPINOL derivatives with desired chiral configurations.
Check Digit Verification of cas no
The CAS Registry Mumber 103438-84-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,4,3 and 8 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 103438-84:
(8*1)+(7*0)+(6*3)+(5*4)+(4*3)+(3*8)+(2*8)+(1*4)=102
102 % 10 = 2
So 103438-84-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H5FO2/c8-7-2-1-6(10)3-5(7)4-9/h1-4,10H
103438-84-2Relevant articles and documents
Desilylation of tert-Butyldimethylsilyl Ethers of Phenols
Sinhababu, Achintya K.,Kawase, Masami,Borchardt, Ronald T.
, p. 710 - 712 (1988)
Treatment of tert-butyldimethylsilyl ethers of phenols and diphenols with potassium fluoride in the presence of catalytic amounts of hydrobromic acid in dimethylformamide generates the corresponding phenols or diphenols in high yields.
COMPOUNDS AND COMPOSITIONS FOR USE IN TREATING SKIN DISORDERS
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, (2021/08/06)
Provided herein is a compound of formula (XXXII) or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer thereof or a physiologically functional derivative thereof, wherein R1, R2, R3, G, A, E, n, p, and q are defined herein. Also provided herein are compositions comprising a compound of formula (XXXII), and methods of using a compound of formula (XXXII), e.g., in the treatment or prevention of skin disorders.
Macrocyclic compounds and methods for their production
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Page/Page column 42, (2015/11/10)
There is provided inter alia compounds of formula (I): for use in treatment of viral infection or as an immunosuppressant.
Novel Dosage Form
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Paragraph 0268; 0269, (2014/09/03)
There is provided inter alia a pharmaceutical dosage form for oral administration comprising a sanglifehrin as active ingredient in which the sanglifehrin active ingredient is protected from acid degradation in the stomach environment following oral admin
