103438-88-6 Usage
Description
2-Fluoro-3-methoxybenzaldehyde is a white to yellow crystalline solid that serves as an essential intermediate in the synthesis of various compounds, particularly benzylidene-1,3-thiazolidine-2,4-diones. These synthesized compounds exhibit potent and selective inhibition of the PIM-1, PIM-2, and PIM-3 protein kinases, making 2-fluoro-3-methoxybenzaldehyde a significant contributor to the development of pharmaceuticals targeting these protein kinases.
Uses
Used in Pharmaceutical Industry:
2-Fluoro-3-methoxybenzaldehyde is used as a key intermediate in the synthesis of benzylidene-1,3-thiazolidine-2,4-diones. These compounds are known for their potent and selective inhibition of PIM-1, PIM-2, and PIM-3 protein kinases, which play a crucial role in various cellular processes, including cell proliferation and survival. By inhibiting these protein kinases, benzylidene-1,3-thiazolidine-2,4-diones can potentially be used in the development of therapeutics for cancer and other diseases associated with the dysregulation of these kinases.
Used in Chemical Synthesis:
2-Fluoro-3-methoxybenzaldehyde can also be utilized in the chemical synthesis of various other compounds due to its unique structure and reactivity. Its fluorinated and methoxy-substituted aromatic ring provides a versatile platform for further functionalization and modification, enabling the creation of a wide range of molecules with diverse applications in different industries, such as materials science, agrochemicals, and pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 103438-88-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,4,3 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 103438-88:
(8*1)+(7*0)+(6*3)+(5*4)+(4*3)+(3*8)+(2*8)+(1*8)=106
106 % 10 = 6
So 103438-88-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H7FO2/c1-11-7-4-2-3-6(5-10)8(7)9/h2-5H,1H3
103438-88-6Relevant articles and documents
Synthesis method of elagolix intermediate
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Paragraph 0113; 0119-0121, (2020/02/17)
The invention relates to a synthesis method of an elagolix intermediate. Specifically, the invention provides a synthesis method of an elagolix intermediate compound X and an elagolix intermediate compound I. According to the method, 2-fluoro-3-methoxy-phenylacetic acid is used as a raw material, and the steps of cyclization, hydrolysis, amino protection, condensation, Mitsunobu reaction and the like are carried out in sequence, so that the elagolix intermediate compound X and the elagolix intermediate compound I are obtained. The method has the advantages of cheap and easily available reagents, high conversion rate, simple operation and low process cost, and is suitable for industrialization.
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
Dakin, Les A.,Block, Michael H.,Chen, Huawei,Code, Erin,Dowling, James E.,Feng, Xiaomei,Ferguson, Andrew D.,Green, Isabelle,Hird, Alexander W.,Howard, Tina,Keeton, Erika K.,Lamb, Michelle L.,Lyne, Paul D.,Pollard, Hannah,Read, Jon,Wu, Allan J.,Zhang, Tao,Zheng, Xiaolan
scheme or table, p. 4599 - 4604 (2012/08/07)
Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The synthesis and SAR of these compounds are described, along with X-ray crystallographic, anti-proliferati
1-AMINO-2-OXY-SUBSTITUTED TETRAHYDRONAPHTALENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS
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Page/Page column 67, (2010/02/11)
The invention relates to polysubstituted tetrahydronaphtalene derivatives of formula (I), to methods for the production thereof, and to their use as antiphlogistics. The substituents are defined in Claim 1.