1034566-09-0Relevant articles and documents
Synthesis and phosphodiesterase 5 inhibitory activity of novel phenyl ring modified sildenafil analogues
Kim, Dae-Kee,Lee, Namkyu,Lee, Ju Young,Ryu, Do Hyun,Kim, Jae-Sun,Lee, Suk-Ho,Choi, Jin-Young,Chang, Kieyoung,Kim, Young-Woo,Im, Guang-Jin,Choi, Won-Son,Kim, Tae-Kon,Ryu, Je-Ho,Kim, Nam-Ho,Lee, Kyoungrim
, p. 1609 - 1616 (2001)
New sildenafil analogues containing an ether ring fused into the phenyl moiety, 6a-d and 7a-d, were efficiently synthesized from the readily available starting materials, 1a-d and 2, in five steps. Ab initio calculations indicated that introduction of a cyclic ether to the phenyl group might enhance the co-planarity of the molecule. The torsional angles were calculated to be 2-3° for the 5-membered cyclic ether derivatives, 6a, 6c, 7a, and 7c, and 12-16° for the 6-membered ones, 6b, 6d, 7b, and 7d. On the other hand, sildenafil showed the least co-planarity with the torsional angle of 23° compared with the target compounds, 6a-d and 7a-d. in the enzyme assay, however, the in vitro PDE 5 inhibitory activity was found out to be inversely related to the degree of co-planarity. In other words, the least planar sildenafil showed the highest actiivty, and the most planar 5-membered cyclic ether derivatives were least active by 100-200-fold compared with sildenafil. Our study clearly demonstrated that the open chain 2'-alkoxy group of the phenyl ring, although less effective for inducing the co-planarity, seemed to act as a much better lipophilic requirement than the cyclic alkoxy moiety. Copyright
