10350-10-4

Basic information

• Product Name: ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE
• Synonyms: ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE;ETHYL-4-HYDROXY-6-METHYL-2-PYRIDONE-3-CARBOXYLATE;AURORA KA-3793;1,2-Dihydro-4-hydroxy-6-methyl-2-(oxo)nicotinic acid ethyl ester;1,2-Dihydro-4-hydroxy-6-methyl-2-oxo-3-pyridinecarboxylic acid ethyl ester;4-Hydroxy-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid ethyl ester
• CAS NO: 10350-10-4
• Molecular Formula: C₉H₁₁NO₄
• Molecular Weight: 197.19
• Product Categories: Building Blocks;C9;Chemical Synthesis;Heterocyclic Building Blocks;New Products for Chemical Synthesis;Pyridines
• Mol File: 10350-10-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 216-222°C
• Boiling Point: 396.5°Cat760mmHg
• Flash Point: 193.6°C
• Appearance: /
• Density: 1.292g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE(10350-10-4)
• EPA Substance Registry System: ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE(10350-10-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 10350-10-4(Hazardous Substances Data)

Usage

Description

ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE, also known as Ethyl 2,4-Dihydroxy-6-methylnicotinate, is a chemical compound that serves as a building block for the synthesis of various chemical compounds. It is characterized by its unique structure, which includes a pyridine ring with hydroxy and methyl substituents, and a carboxylate group attached to an ethyl ester.
Used in Pharmaceutical Industry:
ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE is used as a key intermediate in the synthesis of analogs of Lucanthone, a compound with antitumor and bactericidal properties. Its unique structure allows for the development of new drugs with potential therapeutic applications in cancer treatment and bacterial infections.
Used in Chemical Synthesis:
ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE is used as a versatile building block in the synthesis of various chemical compounds. Its functional groups and structural features make it a valuable component in the creation of new molecules with diverse applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C9H11NO4/c1-3-14-9(13)7-6(11)4-5(2)10-8(7)12/h4H,3H2,1-2H3,(H2,10,11,12)

Upstream product

• 626-34-6 ethyl aminocrotonate 
• 105-53-3 diethyl malonate 
• 3749-51-7 4-hydroxy-6-methyl-2-pyridone 
• 64-17-5 ethanol 
• 846557-80-0 4-hydroxy-6-methyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 

Downstream Products

• 846576-77-0 2,4-dihydroxy-6-methyl-5-(4-nitro-phenylsulfanyl)-nicotinic acid ethyl ester 
• 3749-51-7 2,4-dihydroxy-6-methylpyridine 
• 404875-97-4 2,4-dichloro-6-methyl-nicotinoyl chloride 
• 86129-63-7 ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate 
• 344443-57-8 ethyl 2,4-dihydroxy-5-nitro-6-methylpyridine-3-carboxylate 
• 86129-62-6 ethyl 1,2-dihydro-2-oxo-4-chloro-6-methylpyridine-3-carboxylate 
• 3749-51-7 4-hydroxy-6-methyl-2-pyridone 
• 51146-04-4 ethyl 1,2-dihydro-2-oxo-6-methylpyridine-3-carboxylate 
• 86129-80-8 1,2-dihydro-2-oxo-4-anilino-6-methylpyridine 
• 86129-64-8 1,2-dihydro-2-oxo-4-(phenylthio)-6-methylpyridine-3-carboxylic acid 
• 86129-74-0 ethyl 1,2-dihydro-2-oxo-4-anilino-6-methylpyridine-3-carboxylate 
• 33821-58-8 6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 
• 111974-39-1 Ethyl 4-ethoxy-6-methylpyridine-3-carboxylate 
• 3222-47-7 6-methylnicotinic acid 

Relevant articles and documents

Process method for producing 3-ethyl formate-4-hydroxy-2-pyridone by utilizing carbon dioxide

The invention discloses a process method for producing 3-ethyl formate-4-hydroxy-2-pyridone by utilizing carbon dioxide. The process method comprises the following steps: weighing a 4-hydroxy-6-alkyl-2-pyridone substrate, a catalyst and potassium tert-butoxide to be added into a Schleck bottle, degassing, and continuously introducing 1atm of carbon dioxide; adding a solvent, and reacting in an oilbath; performing after-treatment after the reaction is completed so as to obtain a 3-carboxyl-4-hydroxy-2-pyridone compound 2; carrying out an esterification reaction among the obtained compound 2,(1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), 2-methylaminopyridine and ethanol; performing column chromatography isolation after the reaction is completed, thereby obtaining the 3-ethyl formate-4-hydroxy-2-pyridone 3. According to the process method disclosed by the invention, the used catalyst is wide in source and low in price; the preparation process is simple, the equipment requirement is low, the raw material is wide in source and low in cost, the toxicity is low, and industrial scale-up production is easily realized.

Thermal Cyclization of 3-Acyl-4-azidopyridines to Isoxazolo[4,3-c]pyridines

4-Azidopyridines such as 3-acetyl-4-azido-2-pyridones 3 or 4-azido-3-ethoxycarbonylpyridine 7 with reactive ortho-acyl substituents were obtained from the 4-hydroxy-2-pyridones 1, resp. 5 via 4-tosyloxy-2-pyridones 2 or the 2,4-dichloropyridine 6. DSC-ass