103548-13-6

Basic information

• Product Name: 1,2-Propanediol, 1-benzoate, (2R)-
• Synonyms: (R)-2-hydroxypropyl benzoate;Benzoic acid (R)-2-hydroxy-propyl ester;(2R)-2-hydroxypropyl benzoate
• CAS NO: 103548-13-6
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 103548-13-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,2-Propanediol, 1-benzoate, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Propanediol, 1-benzoate, (2R)-(103548-13-6)
• EPA Substance Registry System: 1,2-Propanediol, 1-benzoate, (2R)-(103548-13-6)

Safety Data

• Hazardous Substances Data: 103548-13-6(Hazardous Substances Data)

Upstream product

• 106-88-7 ethyloxirane 
• 65-85-0 benzoic acid 
• 4254-14-2 (2R)-propane-1,2-diol 
• 98-88-4 benzoyl chloride 
• 57-55-6 propylene glycol 
• 100-52-7 benzaldehyde 
• 15448-47-2 (R)-propylene oxide 
• 6656-60-6 2-oxopropyl benzoate 
• 769-78-8 vinyl benzoate 
• 37086-84-3 2-hydroxypropyl benzoate 

Downstream Products

• 871580-94-8 (1R)-1-methyl-2-phenylcarbonyloxyethyl (2S)-3-(3,4-dihydroxyphenyl)-2-[(tert-butoxy)carbonylamino]propanoate 
• 871580-93-7 (1R)-1-methyl-2-phenylcarbonyloxyethyl (2S)-2-[(tert-butoxy)carbonylamino]-3-[3,4-bis(phenylmethoxy)phenyl]propanoate 

Relevant articles and documents

Synthesis of optically active 2-hydroxy monoesters via-kinetic resolution and asymmetric cyclization catalyzed by heterometallic chiral (salen) Co complex

The binuclear chiral (salen) Co complexes bearing Lewis acids of Al and Ga catalyze regio- and enantioselective ring opening of terminal epoxides with carboxylic acids. The ring opened product of epichlorohydrin with carboxylic acids followed by cyclization step in the presence of catalyst and base represent straightforward, efficient methods for the synthesis of enatiomerically enriched (>99% ee) valuable terminal epoxides. Strong synergistic effects of different Lewis acid of Co-Al and Co-Ga were exhibited in the catalytic process.

Kinetic Resolution of 1,2-Diols via NHC-Catalyzed Site-Selective Esterification

A kinetic resolution of 1,2-diols bearing both a secondary and a primary alcohol motif through an N-heterocyclic carbene-catalyzed oxidative acylation reaction has been developed. A site- and enantioselective esterification reaction is involved for this process. Both the monoacylated diols obtained and the remaining enantioenriched 1,2-diols are versatile building blocks for the preparation of functional molecules with proven biological activities.

LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF

Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. Wherein Q is selected from X-CO-, and -CO-X-; X is selected from-O-, and -NR6-; n is an