1035490-73-3 Usage
Description
(R)-2-Amino-2-(3-trifluoromethylphenyl)ethanol, with the chemical formula C9H12F3NO, is an amino alcohol derivative featuring a fluorinated phenyl group. This chiral compound has its stereochemistry designated as (R), which is significant in various chemical and biological processes. Its unique structure, including the trifluoromethyl group and the amino and hydroxyl functional groups, renders it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other complex compounds.
Uses
Used in Pharmaceutical Synthesis:
(R)-2-Amino-2-(3-trifluoromethylphenyl)ethanol is used as a key intermediate in the pharmaceutical industry for the development of new drugs. The presence of the trifluoromethyl group can enhance the molecule's lipophilicity, metabolic stability, and overall biological activity, making it an attractive candidate for drug design.
Used in Agrochemical Synthesis:
In the agrochemical industry, (R)-2-Amino-2-(3-trifluoromethylphenyl)ethanol serves as a versatile reagent for the synthesis of novel agrochemicals. (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol's unique properties can be harnessed to create more effective and environmentally friendly pesticides, herbicides, and other agricultural products.
Used in Organic Synthesis:
(R)-2-Amino-2-(3-trifluoromethylphenyl)ethanol is utilized as a building block in organic synthesis, allowing chemists to create a wide range of complex molecules with diverse applications. (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol's functional groups and stereochemistry make it a valuable starting material for the development of new materials, catalysts, and other specialty chemicals.
Used in Chemical Research:
As a chiral compound with a fluorinated phenyl group, (R)-2-Amino-2-(3-trifluoromethylphenyl)ethanol is an important tool in chemical research. It can be used to study the effects of stereochemistry and functional group substitution on reaction mechanisms, as well as to explore the potential of fluorinated molecules in various chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 1035490-73-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,5,4,9 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1035490-73:
(9*1)+(8*0)+(7*3)+(6*5)+(5*4)+(4*9)+(3*0)+(2*7)+(1*3)=133
133 % 10 = 3
So 1035490-73-3 is a valid CAS Registry Number.
1035490-73-3Relevant articles and documents
Site-Specific C(sp3)–H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions
Fang, Yuanding,Fu, Kang,Shi, Lei,Zhao, Rong,Zhou, Jia
, p. 20682 - 20690 (2020/09/07)
The utilization of N-centered radicals to synthesize nitrogen-containing compounds has attracted considerable attention recently, due to their powerful reactivities and the concomitant construction of C?N bonds. However, the generation and control of N-centered radicals remain particularly challenging. We report a tethering strategy using SOMO-HOMO-converted distonic radical anions for the site-specific aminations of imidates and amidines with aid of the non-covalent interaction. This reaction features a remarkably broad substrate scope and also enables the late-stage functionalization of bioactive molecules. Furthermore, the reaction mechanism is thoroughly investigated through kinetic studies, Raman spectroscopy, electron paramagnetic resonance spectroscopy, and density functional theory calculations, revealing that the aminations likely involve direct homolytic cleavage of N?H bonds and subsequently controllable 1,5 or 1,6 hydrogen atom transfer.
Formal aromatic C-H insertion for stereoselective isoquinolinone synthesis and studies on mechanistic insights into the C-C bond formation
Park, Chan Pil,Nagle, Advait,Cheol, Hwan Yoon,Chen, Chiliu,Kyung, Woon Jung
supporting information; scheme or table, p. 6231 - 6236 (2009/12/08)
(Chemical Equation Presented) Formal aromatic C-H insertion of rhodium(II) carbenoid was intensively investigated to develop a new methodology and probe its mechanism. Contrasting with the previously proposed direct C-H insertion, the mechanism was revealed to be electrophilic aromatic substitution, which was supported by substituent effects on the aromatic ring and a secondary deuterium kinetic isotope effect. Various isoquinolinones were synthesized intramolecularly via six-membered ring formation with high regioand diastereoselectivity, while averting the common Buchner-type reaction. Intermolecularly, dirhodium catalyzed formal aromatic C-H insertion on electron-rich aromatics was also achieved.
