1035695-10-3

Basic information

• Product Name: 5-[2-(4-fluorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
• Synonyms: 5-[2-(4-fluorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS NO: 1035695-10-3
• Molecular Weight: 280.253
• Mol File: 1035695-10-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 5-[2-(4-fluorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[2-(4-fluorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione(1035695-10-3)
• EPA Substance Registry System: 5-[2-(4-fluorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione(1035695-10-3)

Safety Data

• Hazardous Substances Data: 1035695-10-3(Hazardous Substances Data)

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 405-50-5 p-Fluorophenylacetic acid 

Downstream Products

• 221121-37-5 4-(4-fluorophenyl)-3-oxobutanoic acid ethyl ester 
• 1257337-61-3 (R)-methyl 7-(4-fluorobenzyl)-2,3-dihydro-5-oxo-8-phenylthiazolo[3,2-a]pyridine-3-carboxylate 
• 1052114-80-3 ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate 

Relevant articles and documents

Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics

The lipoxazolidinone family of marine natural products, which contains an unusual 4-oxazolidinone core, was found to possess potent antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA). Herein, we expanded our previous synthet

Practical, asymmetric route to sitagliptin and derivatives: Development and origin of diastereoselectivity

The development of a practical and scalable process for the asymmetric synthesis of sitagliptin is reported. Density functional theory calculations reveal that two noncovalent interactions are responsible for the high diastereoselection. The first is an intramolecular hydrogen bond between the enamide NH and the boryl mesylate S=O, consistent with MsOH being crucial for high selectivity. The second is a novel C-H···F interaction between the aryl C5-fluoride and the methyl of the mesylate ligand.

Synthesis and characterization of a multi ring-fused 2-pyridone-based fluorescent scaffold

A series of compounds based on a novel fluorescent scaffold have been synthesized. Most of the compounds displayed high quantum yields of fluorescence and unusually long fluorescence lifetimes. HeLa cells were treated with one of the compounds and its use as a fluorescent dye was demonstrated with fluorescence confocal microscopy. A multi ring-fused 2-pyridone-based fluorescent scaffold with good quantum yields of fluorescence and ability to stain HeLa-cells is reported.