103594-25-8

Basic information

• Product Name: [1,1-Biphenyl]-3-ol,4,6-dimethoxy-(9CI)
• Synonyms: [1,1-Biphenyl]-3-ol,4,6-dimethoxy-(9CI)
• CAS NO: 103594-25-8
• Molecular Formula: C₁₄H₁₄O₃
• Molecular Weight: 230.25916
• Product Categories: BIPHENYL
• Mol File: 103594-25-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 379.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.144±0.06 g/cm3(Predicted)
• PKA: 10.30±0.18(Predicted)
• CAS DataBase Reference: [1,1-Biphenyl]-3-ol,4,6-dimethoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1-Biphenyl]-3-ol,4,6-dimethoxy-(9CI)(103594-25-8)
• EPA Substance Registry System: [1,1-Biphenyl]-3-ol,4,6-dimethoxy-(9CI)(103594-25-8)

Safety Data

• Hazardous Substances Data: 103594-25-8(Hazardous Substances Data)

Usage

Description

[1,1-Biphenyl]-3-ol,4,6-dimethoxy-(9CI) is a chemical compound with the molecular formula C14H14O3, belonging to the biphenyl family and featuring two methoxy groups at the 4th and 6th positions of the biphenyl ring. [1,1-Biphenyl]-3-ol,4,6-dimethoxy-(9CI) is recognized for its antioxidant and antimicrobial properties, as well as its potential applications in organic synthesis, pharmacology, and medicinal chemistry.

Uses

Used in Organic Synthesis:
[1,1-Biphenyl]-3-ol,4,6-dimethoxy-(9CI) is used as a starting material for the preparation of various biologically active compounds, contributing to the development of novel pharmaceuticals and other bioactive substances.
Used in Antioxidant Applications:
In the field of chemistry, [1,1-Biphenyl]-3-ol,4,6-dimethoxy-(9CI) is used as an antioxidant agent to prevent oxidative degradation in various chemical processes and materials, thereby enhancing their stability and longevity.
Used in Antimicrobial Applications:
[1,1-Biphenyl]-3-ol,4,6-dimethoxy-(9CI) is also utilized as an antimicrobial agent, particularly in the development of new antimicrobial substances that can be applied in the medical, pharmaceutical, and industrial sectors to combat microbial infections.
Used in Pharmacology and Medicinal Chemistry:
[1,1-Biphenyl]-3-ol,4,6-dimethoxy-(9CI) holds potential in the fields of pharmacology and medicinal chemistry, where it can be employed in the design and synthesis of new drugs with therapeutic benefits.

Upstream product

• 103594-23-6 4-methoxy-4-(4-methoxyphenyl)-2,5-cyclohexadienone 
• 111088-09-6 4-methoxy-3-(4-methoxyphenyl)nitrobenzene 
• 122-84-9 4-methoxybenzyl methyl ketone 
• 63801-89-8 4-hydroxy-3-(4-methoxyphenyl)nitrobenzene 
• 2132-80-1 4,4'-Dimethoxybiphenyl 
• 103624-16-4 1-Methoxy-4-(1,4,4-trimethoxy-cyclohexa-2,5-dienyl)-benzene 

Downstream Products

• 111088-11-0 (S)-3-[4-(6,4'-Dimethoxy-biphenyl-3-yloxy)-3,5-dinitro-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester 
• 111088-13-2 (S)-3-[4-(6,4'-Dimethoxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester 
• 111087-84-4 (S)-2-Amino-3-[4-(6,4'-dihydroxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-propionic acid; hydrobromide 

Relevant articles and documents

Thyroid Hormone Analogues. Synthesis of 3'-Substituted 3,5-Diiodo-L-thyronines and Quantitative Structure-Activity Studies of in Vivo Thyromimetic Activities in Rat Liver and Heart

Twenty-nine 3'-substituted derivatives of the thyroid hormone 3,3',5-triiodo-L-thyronine (T3) have been synthesized by using established methods and by new route involving manipulation of a 3'-formyl intermediate.In vitro hormone receptor binding (to intact nuclei) and in vivo thyromimetic activity (induction of mitochondrial 3-phosphoglycerate oxidoreductase, GPDH) were measured in rat liver and heart for these new analogues and for the 18 previously reported 3'-substituted 3,5-diiodo-L-thyronines.Analysis of the binding data using theoretical conformational and quantitative structure-affinity methods implies that the 3'-substituent recognition site on the thyroid hormone receptor is hydrophobic and limited in depth to the length of the natural iodo substituent, but has sufficient width to accomodate a phenyl or cyclohexyl group.Receptor binding is reduced by approximately 10-fold in 3'-acyl derivatives which form strong intramolecular acceptor hydrogen bonds with the ajacent 4'-hydroxyl.The compounds studied showed no differences in their relative affinities for heart and liver nuclei, suggesting that receptors in these tissues are similar.However, the relationships between thyromimetic activity (induction of GPDH) and nuclear binding showed some tissue differences.A high correlation between activity and binding is observed for full agonists in the heart, but an equally significant correlation for the liver data is only seen when 3'-substituent bulk (molar reactivity) is included in the analysis.These results suggest the possibility that differential tissue penetration or access to receptors may occur in vivo.