103628-17-7

Basic information

• Product Name: E-1-<4-(2-chloroethoxy)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene
• Synonyms: E-1-<4-(2-chloroethoxy)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene
• CAS NO: 103628-17-7
• Molecular Weight: 378.898
• Mol File: 103628-17-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: E-1-<4-(2-chloroethoxy)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene(CAS DataBase Reference)
• NIST Chemistry Reference: E-1-<4-(2-chloroethoxy)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene(103628-17-7)
• EPA Substance Registry System: E-1-<4-(2-chloroethoxy)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene(103628-17-7)

Safety Data

• Hazardous Substances Data: 103628-17-7(Hazardous Substances Data)

Upstream product

• 1215295-57-0 (4-(2-chloroethoxy)phenyl)(4-hydroxyphenyl)methanone 
• 93-55-0 1-phenyl-propan-1-one 
• 36603-49-3 4-(tetrahydropyran-2'-yloxy)-1-bromobenzene 
• 103628-22-4 1--2-phenyl-butan-1-one 
• 622-86-6 2-chloroethoxybenzene 
• 108-95-2 phenol 

Relevant articles and documents

High affinity fluorescent ligands for the estrogen receptor

Fluorescent binders of the estrogen receptor (ER) are used in binding assays and in detection or imaging studies. However, fluorescence labelling of ER ligands usually leads to substantial decreases in binding affinity. In this study, we describe the deve

The Use of the Perfluorotolyl Protecting Group in the Synthesis of Pure Z and E Isomers of 4-Hydroxytamoxifen -1-(4-hydroxyphenyl)-2-phenyl-1-butene>

The perfluorotolyl protecting group has been used in the synthesis of pure Z and E isomers of 4-hydroxytamoxifen (4a), a potent metabolite of the anticancer drug, tamoxifen (1a). 4-(Perfluorotolyloxy)phenyl magnesium bromide underwent addition to the carbonyl group of the easily prepared versatile ketone, 1--2-phenyl-1-butanone (7), without affecting the chloroethoxy group.Acid catalysed dehydration of the resulting carbinol gave a 1:1 mixture of isomeric ethers, (6a) and (6b), that were easily separated by chromatography and respectively converted to the Z (4a) and E (4b) isomers of 4-hydroxytamoxifen.The property of the perfluorotolyl function in enabling the separation of geometrical isomers is attributed to a combination of its lipophilicity and electron withdrawal.