1036724-69-2

Basic information

• Product Name: 1-acridin-9-yl-3-{4-[bis(2-chloroethyl)amino]phenyl}urea
• Synonyms: 1-acridin-9-yl-3-{4-[bis(2-chloroethyl)amino]phenyl}urea
• CAS NO: 1036724-69-2
• Molecular Weight: 453.371
• Mol File: 1036724-69-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-acridin-9-yl-3-{4-[bis(2-chloroethyl)amino]phenyl}urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-acridin-9-yl-3-{4-[bis(2-chloroethyl)amino]phenyl}urea(1036724-69-2)
• EPA Substance Registry System: 1-acridin-9-yl-3-{4-[bis(2-chloroethyl)amino]phenyl}urea(1036724-69-2)

Safety Data

• Hazardous Substances Data: 1036724-69-2(Hazardous Substances Data)

Upstream product

• 82484-59-1 4-bis-(β-chloroethyl)aminophenyl isocyanate 
• 134-50-9 acridin-9-amine hydrochloride 
• 806608-18-4 4--phenyl-carbamoylchlorid 

Relevant articles and documents

Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage

To improve the chemical stability and therapeutic efficacy of N-mustard, a series of phenyl N-mustard linked to DNA-affinic 9-anilinoacridines and acridine via a urea linker were synthesized and evaluated for antitumor studies. The new N-mustard derivatives were prepared by the reaction of 4-bis(2-chloroethyl)aminophenyl isocyanate with a variety of 9-anilinoacridines or 9-aminoacridine. The antitumor studies revealed that these agents exhibited potent cytotoxicity in vitro without cross-resistance to taxol or vinblastine and showed potent antitumor therapeutic efficacy in nude mice against human tumor xenografts. It also showed that 24d was capable of inducing marked dose-dependent levels of DNA cross-linking by comet assay and has long half-life in rat plasma.