103694-27-5 Usage
Description
5-Pyrimidinemethanamine, 4-amino(9CI) is a substituted pyrimidine compound, characterized by the presence of an amino group at the 4th position and a methanamine group at the 5th position. It serves as an important intermediate in the synthesis of various chemical compounds, particularly Thiamine (T344185) analogues.
Uses
Used in Pharmaceutical Industry:
5-Pyrimidinemethanamine, 4-amino(9CI) is used as a key intermediate in the synthesis of Thiamine (T344185) analogues for the pharmaceutical industry. Thiamine, also known as vitamin B1, plays a crucial role in energy production and nerve function. The analogues synthesized using this compound may have potential applications in the development of new drugs targeting various health conditions related to Thiamine deficiency or its metabolic pathways.
Used in Chemical Synthesis:
In the field of chemical synthesis, 5-Pyrimidinemethanamine, 4-amino(9CI) is utilized as a building block for creating a wide range of pyrimidine-based compounds. These compounds can be further modified and functionalized to develop new molecules with diverse applications, such as pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
5-Pyrimidinemethanamine, 4-amino(9CI) is also employed in research and development laboratories for studying the structure-activity relationships of pyrimidine-based compounds. This knowledge can be applied to design and develop novel molecules with improved biological activities and selectivity, contributing to the advancement of various scientific fields, including medicinal chemistry, materials science, and biotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 103694-27-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,6,9 and 4 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 103694-27:
(8*1)+(7*0)+(6*3)+(5*6)+(4*9)+(3*4)+(2*2)+(1*7)=115
115 % 10 = 5
So 103694-27-5 is a valid CAS Registry Number.
103694-27-5Relevant articles and documents
Lewis acid-catalyzed synthesis of 4-aminopyrimidines: A scalable industrial process
Letinois, Ulla,Schuetz, Jan,Haerter, Ralph,Stoll, Rinke,Huffschmidt, Florian,Bonrath, Werner,Karge, Reinhard
, p. 427 - 431 (2013)
Pyrimidine synthesis starting from acrylonitrile has been known since the 1960s. The new Lewis acid-catalyzed condensation reaction allows the synthesis of 4-aminopyrimidines starting from the easily accessible chemical acrylonitrile without the need for carcinogenic chemicals and costly derivatization in up to 90% yield. The method is versatile and applicable for industrial-scale synthesis of biologically relevant substances such as vitamin B1 and trimethoprim.
