103733-49-9 Usage
Description
QUINAPRIL RELATED COMPOUND A (50 MG) (ETHYL[3S-[2(R),3A,11A BETA]]-1,3,4,6,11,11A-HEXAHYDRO-3-METHYL-1,4-DIOXO-ALPHA-(2-PHENY-LETHYL)-2H-PYRAZINO[1,2-B]ISOQUINOLINE-2-ACETATE) is a derivative of Quinapril, which is an angiotensin-converting enzyme (ACE) inhibitor. It is a complex organic compound with a molecular structure that includes a hexahydro-3-methyl-1,4-dioxo-2H-pyrazino[1,2-b]isoquinoline-2-acetate core. QUINAPRIL RELATED COMPOUND A (50 MG) (ETHYL[3S-[2(R),3A,11A BETA]]-1,3,4,6,11,11A-HEXAHYDRO-3-METHYL-1,4-DIOXO-ALPHA-(2-PHENY-LETHYL)-2H-PYRAZINO[1,2-B]ISOQUINOLINE-2-ACETATE) is characterized by its potential use in the pharmaceutical industry, particularly for the treatment of hypertension and heart failure.
Uses
Used in Pharmaceutical Industry:
QUINAPRIL RELATED COMPOUND A (50 MG) (ETHYL[3S-[2(R),3A,11A BETA]]-1,3,4,6,11,11A-HEXAHYDRO-3-METHYL-1,4-DIOXO-ALPHA-(2-PHENY-LETHYL)-2H-PYRAZINO[1,2-B]ISOQUINOLINE-2-ACETATE) is used as an ACE inhibitor for the treatment of hypertension and heart failure. As an ACE inhibitor, it helps to relax blood vessels, allowing for better blood flow and reducing the workload on the heart, which can lead to improved cardiovascular health and a lower risk of heart-related complications.
Additionally, as a Quinapril derivative, it may have potential applications in the development of new drugs with improved pharmacological properties, such as enhanced efficacy, reduced side effects, or targeted delivery to specific tissues or organs. Further research and development would be required to explore these possibilities and validate their potential benefits in various therapeutic areas.
Check Digit Verification of cas no
The CAS Registry Mumber 103733-49-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,7,3 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 103733-49:
(8*1)+(7*0)+(6*3)+(5*7)+(4*3)+(3*3)+(2*4)+(1*9)=99
99 % 10 = 9
So 103733-49-9 is a valid CAS Registry Number.
InChI:InChI=1/C25H28N2O4/c1-3-31-25(30)21(14-13-18-9-5-4-6-10-18)27-17(2)23(28)26-16-20-12-8-7-11-19(20)15-22(26)24(27)29/h4-12,17,21-22H,3,13-16H2,1-2H3/t17-,21-,22-/m0/s1
103733-49-9Relevant articles and documents
Effects of a citrate buffer system on the solid-state chemical stability of lyophilized quinapril preparations
Li,Guo,Zografi
, p. 20 - 26 (2002)
Purpose. The objective of this study was to examine the effect of a citric acid-citrate buffer system on the chemical instability of lyophilized amorphous samples of quinapril hydrochloride (QHC1). Methods. Molecular dispersions of QHCI and citric acid were prepared by colyophilization from their corresponding aqueous solutions with a molar ratio of QHCl to citric acid from 1:1 to 6:1 and solution pH from 2.49 to 3.05. Solid samples were subjected to a temperature of 80°C and were analyzed for degradation using high-performance liquid chromatography. The glass transition temperature, Tg, of all samples was measured by differential scanning calorimetry. Results. Samples were first examined by varying the Tg and maintaining the initial solution pH constant. At pH 2.49 the rate of reaction was found to be less dependent on the sample Tg, whereas at pH ≥2.75 the rate decreased with an increase in Tg. In a second set of experiments at a constant Tg of ～70°C, the reaction rate increased as the pH increased. Conclusion. The overall solid-state chemical reactivity of amorphous quinapril depends on the relative amount of QHCl and Q+-, the zwitterionic form of quinapril. At high proportions of Q+- (higher pH values) the reaction rate seems to be strongly influenced by the Tg of the mixture, and hence the molecular mobility, whereas at higher proportions of QHCl (lower pH) the reaction rate is less sensitive to Tg, presumably because of different mechanistic rate determining steps for the two sets of conditions.
