1037479-36-9

Basic information

• Product Name: 4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine
• Synonyms: 4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine;4,6-dichloro-3-(Methylsulfanyl)-1H-pyrazolo[3,4-d]pyriMidine
• CAS NO: 1037479-36-9
• Molecular Formula: C₆H₄Cl₂N₄S
• Molecular Weight: 235.09376
• Product Categories: CHIRAL CHEMICALS
• Mol File: 1037479-36-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.74±0.1 g/cm3(Predicted)
• PKA: 6.71±0.43(Predicted)
• CAS DataBase Reference: 4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine(1037479-36-9)
• EPA Substance Registry System: 4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine(1037479-36-9)

Safety Data

• Hazardous Substances Data: 1037479-36-9(Hazardous Substances Data)

Usage

Description

4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine is a pyrazolopyrimidine derivative, which is a class of compounds known for their potential as Syk and Abl inhibitors. These inhibitors are significant in the treatment of various allergic and autoimmune diseases due to their ability to modulate the immune response.

Uses

Used in Pharmaceutical Industry:
4,6-dichloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine is used as a therapeutic agent for the treatment of allergic and autoimmune diseases. Its application is based on its potential to inhibit Syk and Abl, which are key enzymes involved in the immune response. By inhibiting these enzymes, the compound can help regulate the immune system and alleviate the symptoms of various allergic and autoimmune conditions.
Additionally, the compound may also be used in the development of novel drug delivery systems to enhance its efficacy and bioavailability, similar to the applications of gallotannin in the field of cancer treatment. This could involve the use of organic or metallic nanoparticles as carriers for improved delivery and therapeutic outcomes.

Upstream product

• 1037479-34-7 3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione 

Downstream Products

• 1037479-69-8 3-(6-chloro-3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)benzonitrile 
• 1037479-19-8 3-(Methylthio)-N₆-(4-morpholinophenyl)-N₄-(thiazol-2-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine 
• 1037479-66-5 N-(4-(6-chloro-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenyl)acetamide 

Relevant articles and documents

PYRAZOLOPYRIMIDINE COMPOUND

Disclosed is a novel compound having Syk and/or Abl inhibitory activities, which is useful for prevention/treatment of allergic diseases, autoimmune diseases, arthritides and cancers. Specifically disclosed is a pyrazolopyrimidine compound represented by