103802-01-3

Basic information

• Product Name: (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-succinic acid
• CAS NO: 103802-01-3
• Molecular Weight: 511.596
• Mol File: 103802-01-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-succinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-succinic acid(103802-01-3)
• EPA Substance Registry System: (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-succinic acid(103802-01-3)

Safety Data

• Hazardous Substances Data: 103802-01-3(Hazardous Substances Data)

Upstream product

• 56-84-8 L-aspartic acid 
• 3674-06-4 (tert-butoxycarbonyl)-L-phenylalanine N-hydroxysuccinimide ester 

Downstream Products

• 111193-56-7 (S)-2-((S)-2-{(S)-2-[((S)-3-tert-Butoxycarbonyl-thiazolidine-4-carbonyl)-amino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyrylamino)-succinic acid 
• 103802-02-4 (S)-2-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyrylamino)-succinic acid 

Relevant articles and documents

TRIMETHYLSILYL CYANIDE, A REAGENT AND (CO)SOLVENT "PAR EXCELLENCE" FOR HOMOGENOUS PEPTIDE SYNTHESIS. A STRATEGY CIRCUMVENTING CLASSICAL DRAWBACKS? PART I

Attention is called for a superb strategy of peptide synthesis in solution, making use of (per)silylated amino acide fragments.This old methodology may thus present renewed interest if the classical silylation is substituted by silyl cyanides during coupling.Thus, trimethylsilyl cyanide, by its pronounced silylating power affording only gaseous following-(by)products and by its excellent solubilizing properties in organic solvents, overcomes the difficulties and drawbacks that were encountered in previously described strategies that made use of extempore prepared (per)silylated amino acid residues.