1038304-17-4Relevant articles and documents
Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant
Muraglia, Ester,Kinzel, Olaf D.,Laufer, Ralph,Miller, Michael D.,Moyer, Gregory,Munshi, Vandna,Orvieto, Federica,Palumbi, Maria Cecilia,Pescatore, Giovanna,Rowley, Michael,Williams, Peter D.,Summa, Vincenzo
, p. 2748 - 2752 (2007/10/03)
A series of aryltetrazolylacetanilides was synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors on wild-type virus and on the clinically relevant K103N mutant strain. Extensive SAR investigation led to potent compounds, with nanomolar activity on K103N, and orally bioavailable in rats.