1038342-55-0

Basic information

• Product Name: C₁₆H₁₂Cl₃NO₄
• CAS NO: 1038342-55-0
• Molecular Weight: 388.635
• Mol File: 1038342-55-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₂Cl₃NO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₂Cl₃NO₄(1038342-55-0)
• EPA Substance Registry System: C₁₆H₁₂Cl₃NO₄(1038342-55-0)

Safety Data

• Hazardous Substances Data: 1038342-55-0(Hazardous Substances Data)

Upstream product

• 638-32-4 succinamic acid 
• 3380-34-5 triclosan 

Relevant articles and documents

Design, synthesis, and application of novel triclosan prodrugs as potential antimalarial and antibacterial agents

A number of new triclosan-conjugated analogs bearing biodegradable ester linkage have been synthesized, characterized and evaluated for their antimalarial and antibacterial activities. Many of these compounds exhibit good inhibition against Plasmodium falciparum and Escherichia coli. Among them tertiary amine containing triclosan-conjugated prodrug (5) inhibited both P. falciparum (IC50; 0.62 μM) and E. coli (IC50; 0.26 μM) at lower concentrations as compared to triclosan. Owing to the presence of a cleavable ester moiety, these new prodrugs are hydrolyzed under physiological conditions and parent molecule, triclosan, is released. Further, introduction of tertiary/quaternary functionality increases their cellular uptake. These properties impart them with higher potency to their antimalarial as well as antibacterial activities. The best compound among them 5 shows close to four-fold enhanced activities against P. falciparum and E. coli cultures as compared to triclosan.