103845-98-3

Basic information

• Product Name: AURORA KA-785
• Synonyms: AURORA KA-785;6-BROMO-3,9-DIHYDRO-1,3,4,9-TETRAAZA-FLUORENE-2-THIONE;6-Bromo-9H-1,3,4,9-tetraaza-fluorene-2-thiol
• CAS NO: 103845-98-3
• Molecular Formula: C₉H₅BrN₄S
• Molecular Weight: 281.13
• Mol File: 103845-98-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 338.4°C at 760 mmHg
• Flash Point: 158.5°C
• Appearance: /
• Density: 2.12g/cm³
• Vapor Pressure: 9.83E-05mmHg at 25°C
• Refractive Index: 1.943
• CAS DataBase Reference: AURORA KA-785(CAS DataBase Reference)
• NIST Chemistry Reference: AURORA KA-785(103845-98-3)
• EPA Substance Registry System: AURORA KA-785(103845-98-3)

Safety Data

• Hazardous Substances Data: 103845-98-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H5BrN4S/c10-4-1-2-6-5(3-4)7-8(11-6)12-9(15)14-13-7/h1-3,13H,(H,14,15)

Upstream product

• 4553-11-1 2-(5-bromo-2,3-dihydro-2-oxo-1H-indol-3-ylidene)hydrazinecarbothioamide 
• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 79-19-6 thiosemicarbazide 
• 129951-97-9 5-oxo-6-(2-amino-5-bromophenyl)-1,2,4-triazine-3-thione 
• 66475-83-0 N-(4-bromophenyl)-2-(hydroxyimino) acetamide 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 141178-05-4 8-bromo-3-phenacylthio-5H-1,2,4-triazino<5,6-b>indole 
• 121006-68-6 2-(8-Bromo-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-1-p-tolyl-ethanone; hydrobromide 
• 121006-66-4 5H-3-(p-Chlorophenacylthio)-8-bromo <1,2,4>triazino<5,6-b>indole hydrobromide 
• 121006-67-5 5H-3-(p-Bromophenacylthio)-8-bromo <1,2,4>triazino<5,6-b>indole hydrobromide 
• 113361-44-7 N-(8-Bromo-5H-[1,2,4]triazino[5,6-b]indol-3-yl)-N'-[1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 113361-48-1 N-(8-Bromo-5H-[1,2,4]triazino[5,6-b]indol-3-yl)-N'-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazine 
• 113387-47-6 {4-[(8-Bromo-5H-[1,2,4]triazino[5,6-b]indol-3-yl)-hydrazonomethyl]-phenyl}-dimethyl-amine 
• 113387-49-8 2-(8-Bromo-5H-[1,2,4]triazino[5,6-b]indol-3-yl)-5-phenyl-2H-pyrazol-3-ylamine 
• 113387-48-7 N-(8-Bromo-5H-[1,2,4]triazino[5,6-b]indol-3-yl)-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 113412-69-4 2-(8-Bromo-5H-[1,2,4]triazino[5,6-b]indol-3-yl)-5-(4-chloro-phenyl)-2H-pyrazol-3-ylamine 
• 113387-50-1 5-(4-Bromo-phenyl)-2-(8-bromo-5H-[1,2,4]triazino[5,6-b]indol-3-yl)-2H-pyrazol-3-ylamine 
• 141178-06-5 7-bromo-3-phenylthiazolo<3',2':2,3><1,2,4>triazino<5,6-b>indole 
• 121006-75-5 6-Bromo-3-p-tolyl-1-thia-3a,4,9,10-tetraaza-cyclopenta[b]fluorene 
• 121006-74-4 7-Bromo-3-(p-bromophenyl)thiazolo<3',2':2,3><1,2,4>triazino<5,6-b>indole 

Relevant articles and documents

Further Studies on Triazinoindoles as Potential Novel Multitarget-Directed Anti-Alzheimer's Agents

The inadequate clinical efficacy of the present anti-Alzheimer's disease (AD) drugs and their low impact on the progression of Alzheimer's disease in patients have revised the research focus from single targets to multitarget-directed ligands. A novel series of substituted triazinoindole derivatives were obtained by introducing various substituents on the indole ring for the development of multitarget-directed ligands as anti-AD agents. The experimental data indicated that some of these compounds exhibited significant anti-AD properties. Among them, 8-(piperidin-1-yl)-N-(6-(pyrrolidin-1-yl)hexyl)-5H-[1,2,4]triazino[5,6-b]indol-3-amine (60), the most potent cholinesterase inhibitor (AChE, IC50 value of 0.32 μM; BuChE, IC50 value of 0.21 μM), was also found to possess significant self-mediated Aβ1-42 aggregation inhibitory activity (54% at 25 μM concentration). Additionally, compound 60 showed strong antioxidant activity. In the PAMPA assay, compound 60 exhibited blood-brain barrier penetrating ability. An acute toxicity study in rats demonstrated no sign of toxicity at doses up to 2000 mg/kg. Furthermore, compound 60 significantly restored the cognitive deficits in the scopolamine-induced mice model and Aβ1-42-induced rat model. In the in silico ADMET prediction studies, the compound satisfied all the parameters of CNS acting drugs. These results highlighted the potential of compound 60 to be a promising multitarget-directed ligand for the development of potential anti-AD drugs.

Indole derivative and application thereof

The invention discloses an indole derivative. The indole derivative is an indole structure-containing derivative with a novel structure. Through test of the in-vitro anti-tumor activity, it is found that the indole derivative has a remarkable anti-tumor effect and can be applied to preparation of medicine for treating or preventing cancer diseases and other proliferative diseases, so that treatment or prevention of cancer diseases and other proliferative diseases is achieved. Therefore, the indole derivative has an excellent application prospect in the aspect of development of anti-tumor medicine.

Triazino indole-quinoline hybrid: A novel approach to antileishmanial agents

A novel series of 1,2,4-triazino-[5,6b]indole-3-thione covalently linked to 7-chloro-4-aminoquinoline have been synthesized and evaluated for their in vitro activity against extracellular promastigote and intracellular amastigote form of Leishmania donovani. Among all tested compounds, compounds 7a and 7b were found to be the most active with IC50 values 1.11, 0.36 μM and selectivity index (SI) values 67, >1111, respectively, against amastigote form of L. donovani which is several folds more potent than the standard drugs, miltefosine (IC50 = 8.10 μM, SI = 7) and sodium stibo-gluconate (IC50 = 54.60 μM, SI ≥ 7).