1038478-81-7

Basic information

• Product Name: ethyl 2-[(4-cyanobenzyl)amino]-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-7-carboxylate
• Synonyms: ethyl 2-[(4-cyanobenzyl)amino]-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-7-carboxylate
• CAS NO: 1038478-81-7
• Molecular Weight: 365.389
• Mol File: 1038478-81-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-[(4-cyanobenzyl)amino]-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[(4-cyanobenzyl)amino]-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-7-carboxylate(1038478-81-7)
• EPA Substance Registry System: ethyl 2-[(4-cyanobenzyl)amino]-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-7-carboxylate(1038478-81-7)

Safety Data

• Hazardous Substances Data: 1038478-81-7(Hazardous Substances Data)

Upstream product

• 1038478-77-1 ethyl 2-bromo-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-7-carboxylate 
• 10406-25-4 4-aminobenzyl cyanide 

Downstream Products

• 1038478-87-3 3-hydroxy-4-(methylamino)benzoic acid 
• 105-07-7 4-cyanobenzaldehyde 
• 1038478-90-8 3,4-dihydro-2-hydroxy-4-methyl-3-oxo-2H-1,4-benzoxazine-7-carboxylic acid 
• 66389-80-8 tert-butyl N-[(4-cyanophenyl)methyl]carbamate 

Relevant articles and documents

Ring opening of 2-(benzylamino)-2H-1,4-benzoxazin-3(4H)-ones and 2-bromo-2H-1,4-benzoxazin-3(4H)-ones

Substituted 2-(benzylamino)-2H-1,4-benzoxazin-3(4H)-ones are unstable under alkaline and acidic conditions, undergoing opening of the benzoxazinone ring. 2-Bromo-2H-1,4-benzoxazin-3(4H)-ones show similar degradation under alkaline conditions, while replacement of Br at C(2) to give 2-hydroxy-2H-1,4-benzoxazin- 3(4H)-ones was observed only under mild alkaline conditions. Mechanisms of ring opening and degradation to 2-aminophenol derivatives are proposed.