103853-88-9

Basic information

• Product Name: 4-HYDROXY-2-METHYL-QUINOLINE-6-CARBOXYLIC ACID
• Synonyms: TIMTEC-BB SBB011040;4-HYDROXY-2-METHYL-QUINOLINE-6-CARBOXYLIC ACID;4-Hydroxy-2-methyl-6-quinolinecarboxylic acid
• CAS NO: 103853-88-9
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.19
• Mol File: 103853-88-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: >300 °C
• Boiling Point: 404.3°C at 760 mmHg
• Flash Point: 198.3°C
• Appearance: /
• Density: 1.331g/cm³
• Vapor Pressure: 2.92E-07mmHg at 25°C
• Refractive Index: 1.613
• PKA: 3.24±0.30(Predicted)
• CAS DataBase Reference: 4-HYDROXY-2-METHYL-QUINOLINE-6-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-2-METHYL-QUINOLINE-6-CARBOXYLIC ACID(103853-88-9)
• EPA Substance Registry System: 4-HYDROXY-2-METHYL-QUINOLINE-6-CARBOXYLIC ACID(103853-88-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 103853-88-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 43, p. 4667, 2000 DOI: 10.1021/jm0002073Journal of the American Chemical Society, 77, p. 6682, 1955 DOI: 10.1021/ja01629a106

InChI:InChI=1/C11H9NO3/c1-6-4-10(13)8-5-7(11(14)15)2-3-9(8)12-6/h2-5H,1H3,(H,12,13)(H,14,15)

Upstream product

• 100136-28-5 4-methoxy-2-methyl-quinoline-6-carbonitrile 
• 108877-58-3 4-(2-ethoxycarbonyl-1-methyl-vinylamino)-benzoic acid 
• 593287-13-9 ethyl 4-hydroxy-2-methylquinoline-6-carboxylate 
• 94-09-7 p-aminoethylbenzoate 
• 141890-72-4 ethyl 3-(4-ethoxycarbonyl)phenylaminocrotonate 
• 150-13-0 4-amino-benzoic acid 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 941252-09-1 N-benzyl-4-hydroxy-2-methylquinoline-6-carboxamide 
• 321534-84-3 4-hydroxy-2-methyl-quinoline-6-carboxylic acid (2-phenoxymethyl-phenyl)-amide 
• 321534-85-4 4-methoxyquinoline-6-carboxamide 
• 137872-96-9 4-amino-2-methylquinoline-6-carboxylic acid benzylamide 
• 450379-86-9 2-methyl-4-oxo-1,4-dihydro-quinoline-6-carboxylic acid methyl ester 

Relevant articles and documents

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2-PROPENE-1-ONES AS HSP 70 INDUCERS

The present invention relates to novel compounds of 2-propene-1-one series, of general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, wherein R5, R6, Q and Y are as defined in the specification. The present invention also relates to a process for preparing such compounds, compositions containing such compounds, and use of such compound and composition in medicine. The compounds of the general formula (I) induce HSP-70 and are useful for the treatment of diseases accompanying pathological stress in a living mammalian organism, including a human being, such as stroke, myocardial infarction, inflammatory disorder, hepatotoxicity, sepsis, diseases of viral origin, allograft rejection, tumourous diseases, gastric mucosal damage, brain haemorrhage, endothelial dysfunctions, diabetic complications, neuro-degenerative diseases, post-traumatic neuronal damage, acute renal failure, glaucoma and aging related skin degeneration.