103859-67-2

Basic information

• Product Name: 1-iodo-2-(4-nitrophenoxy)benzene
• Synonyms: 1-iodo-2-(4-nitrophenoxy)benzene
• CAS NO: 103859-67-2
• Molecular Weight: 341.105
• Mol File: 103859-67-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-iodo-2-(4-nitrophenoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-iodo-2-(4-nitrophenoxy)benzene(103859-67-2)
• EPA Substance Registry System: 1-iodo-2-(4-nitrophenoxy)benzene(103859-67-2)

Safety Data

• Hazardous Substances Data: 103859-67-2(Hazardous Substances Data)

Upstream product

• 533-58-4 2-Iodophenol 
• 350-46-9 4-Fluoronitrobenzene 
• 100-02-7 4-nitro-phenol 
• 1493-27-2 ortho-nitrofluorobenzene 
• 18226-25-0 2-(4-nitrophenoxy)benzenamine 
• 5950-83-4 2,4'-dinitrodiphenyl ether 
• 615-42-9 1,2-Diiodobenzene 
• 24067-17-2 4-nitrophenylboronic acid 
• 129112-26-1 2-iodophenyltrifluoromethanesulfonic acid 
• 34883-46-0 1-(2-iodophenoxy)benzene 

Downstream Products

• 307308-63-0 4-(2-iodo-phenoxy)-aniline 

Relevant articles and documents

Structure-Based Optimization of 3-Phenyl-N-(2-(3-phenylureido)ethyl)thiophene-2-sulfonamide Derivatives as Selective Mcl-1 Inhibitors

Selective Mcl-1 inhibitors may overcome the drug resistance caused by current anti-apoptotic Bcl-2 protein inhibitors in tumors with Mcl-1 overexpression. Based on previously discovered compounds with a 3-phenylthiophene-2-sulfonamide core moiety, in this work, we have obtained new compounds with improved binding affinity and/or selectivity under the guidance of structure-based design. The most potent compounds achieved sub-micromolar binding affinities to Mcl-1 (Ki～ 0.4 μM) and good cytotoxicity (IC5015N-heteronuclear single-quantum coherence NMR spectra suggested that these compounds bound to the BH3-binding groove on Mcl-1. Several cellular assays revealed that FWJ-D4 as well as its precursor FWJ-D5 effectively induced caspase-dependent apoptosis, and their target engagement at Mcl-1 was confirmed by co-immunoprecipitation experiments. Treatment with FWJ-D5 at 50 mg/kg every 2 days on an RS4;11 xenograft mouse model for 22 days led to 75% reduction in tumor volume without body weight loss.

Intramolecular Aryl Migration of Diaryliodonium Salts: Access to ortho-Iodo Diaryl Ethers

By using vicinal trifluoromethanesulfonate-substituted diaryliodonium salts, a novel approach was developed for the synthesis of ortho-iodo diaryl ethers by intramolecular aryl migration. The reaction conditions are mild with a broad substrate scope. Mechanistic insight suggests a sulfonyl-directed nucleophilic aromatic substitution pathway. Additionally, the product ortho-iodo diaryl ethers serve as versatile synthons as demonstrated with several coupling reactions. Furthermore, a useful thyroxine analogue of the 3-iodo-l-thyronine (3-T1) derivative was synthesized by this aryl migration procedure.