103876-98-8

Basic information

• Product Name: 4-Hydroxy Omeprazole Sulfide
• Synonyms: 4-Hydroxy Omeprazole Sulfide;EsoMeprazole related substance;2-[[(5-Methoxy-1H-benziMidazol-2-yl)thio]Methyl]-3,5-diMethyl-4-pyridinol;2-[[(6-Methoxy-1H-benziMidazol-2-yl)thio]Methyl]-3,5-diMethyl-4-pyridinol;OMeprazole Pyridone;EsoMeprazole H215/01;EsoMeprazole related substanceH215/0
• CAS NO: 103876-98-8
• Molecular Formula: C16H16N3O2S
• Molecular Weight: 314.38214
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 103876-98-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 654.9±65.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• Storage Temp.: Amber Vial, -20?C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• PKA: 5.69±0.28(Predicted)
• Stability: Light Sensitive
• CAS DataBase Reference: 4-Hydroxy Omeprazole Sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy Omeprazole Sulfide(103876-98-8)
• EPA Substance Registry System: 4-Hydroxy Omeprazole Sulfide(103876-98-8)

Safety Data

• Hazardous Substances Data: 103876-98-8(Hazardous Substances Data)

Usage

Description

4-Hydroxy Omeprazole Sulfide is an intermediate compound used in the synthesis of Omeprazole metabolites. It is a pale yellow solid with specific chemical properties that make it a crucial component in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
4-Hydroxy Omeprazole Sulfide is used as an intermediate in the preparation of Omeprazole metabolites for the development of medications that target gastric acid-related disorders. Its role in the synthesis process is vital for creating effective drugs that can manage conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and other acid-related issues.
The compound's chemical properties and its position in the synthesis process make it a valuable asset in the pharmaceutical industry, contributing to the creation of life-enhancing medications for a wide range of patients.

Upstream product

• 73590-85-9 6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole 

Relevant articles and documents

Chemoselective Demethylation of Methoxypyridine

A chemoselective demethylation method for various methoxypyridine derivatives has been developed. Treatment of 4-methoxypyridine with L-selectride in THF for 2 h at reflux temperature afforded 4-hydroxypyridine in good yield; no reaction to anisole occurred. The utility of our method was demonstrated by the efficient synthesis of the metabolic substances of the antiulcer agent omeprazole. Chemoselective demethylation at the site of 3,5-dimethyl-4-methoxypyridine in the presence of 4-methoxybenzimidazole was achieved.