1038915-73-9

Basic information

• Product Name: MK-4827 (tosylate)
• Synonyms: MK-4827 (tosylate);(3S)-3-[4-[7-(Aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidine tosylate;Niraparib TsOH;niraparib p-toluenesulfonate;MK-4827(Niraparib) tosylate;Niraparib Tosylate;MK-4827, Niraparib TsOH salt
• CAS NO: 1038915-73-9
• Molecular Formula: C₇H₈O₃S*C₁₉H₂₀N₄O
• Molecular Weight: 492.58992
• Mol File: 1038915-73-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Methanol (Slightly)
• CAS DataBase Reference: MK-4827 (tosylate)(CAS DataBase Reference)
• NIST Chemistry Reference: MK-4827 (tosylate)(1038915-73-9)
• EPA Substance Registry System: MK-4827 (tosylate)(1038915-73-9)

Safety Data

• Hazardous Substances Data: 1038915-73-9(Hazardous Substances Data)

Upstream product

• 1038916-11-8 tert-butyl (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidine-1-carboxylate 
• 104-15-4 toluene-4-sulfonic acid 
• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 1284448-67-4 isopropyl 4-(4-bromophenyl)-4-oxobutanoate 
• 1476776-39-2 isopropyl 3-(2-(4-bromophenyl)oxiran-2-yl)-propanoate 
• 1476776-40-5 isopropyl 4-(4-bromophenyl)-5-oxopentanoate 
• 1476776-44-9 (S)-5-(4-bromophenyl)piperidin-2-one 
• 1476776-53-0 (S)-3-(4-bromophenyl)piperidin-1-ium 4-methylbenzenesulfonate 
• 1335523-82-4 4-(3S-piperidine-3-yl)bromobenzene 
• 1476776-55-2 (S)-3-(4-bromophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1476776-76-7 N‐tert‐butyl‐1H‐indazole‐7‐carboxamide 
• 1476776-62-1 C₁₁H₁₆BrNO 
• 1476776-64-3 (S)-tert-butyl (2-(4-bromophenyl)-5-hydroxypentyl)carbamate 
• 1476776-66-5 (S)-4-(4-bromophenyl)-5-((tert-butoxycarbonyl)amino)pentyl methanesulfonate 

Downstream Products

• 1038915-60-4 (3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF

The present invention relates to novel procedures and novel intermediates useful in the synthesis of Niraparib or any salt thereof.

Process development of C-N cross-coupling and enantioselective biocatalytic reactions for the asymmetric synthesis of niraparib

Process development of the synthesis of the orally active poly(ADP-ribose)polymerase inhibitor niraparib is described. Two new asymmetric routes are reported, which converge on a high-yielding, regioselective, copper-catalyzed Narylation of an indazole derivative as the late-stage fragment coupling step. Novel transaminase-mediated dynamic kinetic resolutions of racemic aldehyde surrogates provided enantioselective syntheses of the 3-aryl-piperidine coupling partner. Conversion of the C-N cross-coupling product to the final API was achieved by deprotection and salt metathesis to isolate the desired crystalline salt form.