1038924-76-3

Basic information

• Product Name: (3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1038924-76-3
• Molecular Weight: 365.472
• Mol File: 1038924-76-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester(1038924-76-3)
• EPA Substance Registry System: (3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester(1038924-76-3)

Safety Data

• Hazardous Substances Data: 1038924-76-3(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 171288-20-3 N-boc-(2S,4R)-4-methylpyroglutamic acid 
• 1361408-15-2 (R)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 
• 1174130-72-3 (R)-5-biphenyl-4-ylmethyl-3-methylene-2-oxo-pyrrolidine-1-carboxylic acid tert-butylester 
• 1174130-65-4 (R)-5-biphenyl-4-ylmethyl-3-[1-dimethylaminometh-(E/Z)-ylidene]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1038924-70-7 (3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one 
• 1038924-65-0 (S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethyl-propionyl)-pyrrolidin-2-one 
• 74-88-4 methyl iodide 
• 109-72-8 n-butyllithium 
• 108-18-9 diisopropylamine 
• 17342-08-4 (S)-Pyroglutaminol 
• 5122-94-1 4-biphenylboronic acid 
• 3315-91-1 4-biphenylylmagnesium bromide 
• 135697-21-1 (S)-(1-tert-butoxycarbonyl-5-oxopyrrolidin-2-yl)-methyl-4-methylbenzenesulfonate 

Downstream Products

• 1012341-50-2 (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid 
• 1012341-54-6 (2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid 
• 1038924-79-6 (3S,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1361408-15-2 (R)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 
• 149709-62-6 α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate 
• 149709-60-4 ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate 
• 149690-12-0 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride 

Relevant articles and documents

Compound for preparing sacubitril and preparation method and applications thereof

The invention provides a compound for preparing sacubitril and a preparation method and applications thereof. The compound has structures represented by the formula I and the formula II. The compoundhas two chiral centers. When the compound is applied to prepare sacubitril, complicated low-yield-selectivity reactions for introducing chiral groups are avoided completely, the reaction efficiency isgreatly improved; and the reaction steps are shortened. The compound represented by the formula I and the formula II can be used to prepare a sacubitril intermediate namely (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-ethyl methyl valerate. The preparation method only comprises several simple steps, does not contain any reaction for introducing chiral centers, has the advantages of short synthesisroute, low synthesis cost, and convenient operation, and is suitable for industrial production.

Novel synthesis method of key component Sacubitril of novel anti-heart-failure drug

The invention discloses a novel synthesis method of key component Sacubitril of a novel anti-heart-failure drug. The method includes transforming a starting material compound 1 to a compound 2; coupling the compound 2 with (1'1)-4-biphenylmagnesium bromide to obtain a compound 3; subjecting the compound 3 to hydrolysis reaction by loading a Boc protecting group, and preparing a compound 5 by means of one-pot reaction; subjecting the compound 5 to Boc group removal and esterification reaction to obtain a compound 6, and reacting the compound 6 with succinic anhydride without separation to obtain a compound 7, namely Sacubitril, wherein the route is as following.

NEW PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE MANUFACTURE NEP INHIBITORS

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