1039103-85-9

Basic information

• Product Name: 7-phenyl-2,3,6,7-tetrahydrobenzofuran-4(5H)-one
• CAS NO: 1039103-85-9
• Molecular Weight: 214.264
• Mol File: 1039103-85-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-phenyl-2,3,6,7-tetrahydrobenzofuran-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-phenyl-2,3,6,7-tetrahydrobenzofuran-4(5H)-one(1039103-85-9)
• EPA Substance Registry System: 7-phenyl-2,3,6,7-tetrahydrobenzofuran-4(5H)-one(1039103-85-9)

Safety Data

• Hazardous Substances Data: 1039103-85-9(Hazardous Substances Data)

Upstream product

• 14113-94-1 2-phenyl-1-cyclopropylethan-1-one 
• 292638-85-8 acrylic acid methyl ester 

Relevant articles and documents

Lewis acid-mediated reactions of 1-cyclopropyl-2-arylethanone derivatives with allenic ester, ethyl acetoacetate, and methyl acrylate

(Chemical Equation Presented) TMSOTf-mediated reactions of 2-aryl-1-(1-phenylcyclopropyl)ethanones 1 with allenic esters afford a novel method for the synthesis of 6-methyl-3a,7-diaryl-3,3a-dihydro-2H-benzofuran-4- one derivatives 2 in moderate yields. In addition, we also found that TMSOTf-mediated reactions of 1-cyclopropyl-2-arylethanones with ethyl acetoacetate can provide the corresponding 2,3-dihydrobenzofuran-4-ol and dihydrofuro[2,3-h]chromen-2-one in moderate yields via a sequential reaction involving a nucleophilic ring-opening reaction of the cyclopropane by H 2O, one intermolecular aldol type reaction and two intramolecular aldol type reactions, a cyclic transesterification, dehydration, and aromatization. Moreover, by using methyl acrylate to replace allenic ester, the corresponding 7-aryl-3,5,6,7-tetrahydro-2H-benzofuran-4-one and 5-aryl-3,5,6,7-tetrahydro-2H-benzofuran-4-one can be formed in moderate to high yields in the presence of Bi(OTf)2Cl. Plausible reaction mechanisms have also been provided on the basis of control experiments.