103914-50-7

Basic information

• Product Name: 4-chloro-6-fluoro-2-(4-fluorophenyl)quinoline
• Synonyms: 4-chloro-6-fluoro-2-(4-fluorophenyl)quinoline
• CAS NO: 103914-50-7
• Molecular Weight: 275.685
• Mol File: 103914-50-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-chloro-6-fluoro-2-(4-fluorophenyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-6-fluoro-2-(4-fluorophenyl)quinoline(103914-50-7)
• EPA Substance Registry System: 4-chloro-6-fluoro-2-(4-fluorophenyl)quinoline(103914-50-7)

Safety Data

• Hazardous Substances Data: 103914-50-7(Hazardous Substances Data)

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 391-77-5 4-Chloro-6-fluoroquinoline 

Downstream Products

• 103914-20-1 1-[6-fluoro-2-(4-fluorophenyl)-4-quinolinyl]-4-piperidinecarboxamide 

Relevant articles and documents

Oxadiazoles as bioisosteric transformations of carboxylic functionalities. II

In order to improve the in vivo efficacy of a series of known benzodiazepine receptor (BZR) ligands, 1-(2-phenyl-4-quinolinyl)-4-piperidinecarboxamides, a series of analogs has been prepared in which the amide group of these ligands has been replaced by a 1,2,4-oxadiazole moiety or converted to other carboxylic isosters such as esters or nitriles. An increase in the in vivo efficacy was observed for some of the compounds prepared in this investigation compared to the parent carboxamide derivatives.