103941-98-6Relevant articles and documents
Rapid and stereochemically flexible synthesis of polypropionates: Super-silyl-governed aldol cascades
Brady, Patrick B.,Yamamoto, Hisashi
, p. 1942 - 1946 (2012/04/04)
Polypropionates made EZ: The E/Z geometry of tris(trimethylsilyl)silyl super silyl enol ethers derived from propionaldehyde controls diastereoselectivity in the aldehyde crossed-aldol reaction. These silyl enol ethers can participate in polyaldol cascade reactions, thus allowing the one-pot synthesis of four different dipropionate stereotetrads (see scheme), and polyketides bearing up to five contiguous stereocenters.