1039750-63-4Relevant articles and documents
Asymmetric Synthesis of Pyrrolidine-Containing Chemical Scaffolds via Tsuji–Trost Allylation of N-tert-Butanesulfinyl Imines
Dawood, Rafid S.,Georgiou, Irene,Wilkie, Ross P.,Lewis, William,Stockman, Robert A.
, p. 11153 - 11158 (2017)
A simple and efficient asymmetric synthesis of novel sp3-rich pyrrolidine chemical scaffolds over five steps starting from simple ketones is described. Key steps involve the use of tert-butanesulfinamide as a chiral auxiliary to perform an asym
N-BIPHENYLMETHYLBENZIMIDAZOLE MODULATORS OF PPARG
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Page/Page column 58-59, (2013/06/06)
The invention provides molecular entities that bind with high affinity to PPARG (PPAR?), inhibit cdk5-mediated phosphorylation of PPARG, but do not exert an agonistic effect on PPARG. Compounds of the invention can be used for treatment of conditions in patients wherein PPARG plays a role, such as diabetes or obesity. Methods of preparation of the compounds, bioassay methods for evaluating compounds of the invention as non-agonistic PPARG binding compounds, and pharmaceutical compositions are also provided.