103986-76-1Relevant articles and documents
Facile syntheses of 4-hydroxy-7-methyl-1-indanone, isolated from cyanobacterium Nostoc commune
Kamat, Shrivallabh P.,Menezes, Jose C.,Siddhaye, Bhushan M.,Paknikar, Shashikumar K.
experimental part, p. 1597 - 1599 (2009/04/07)
Two different high yielding synthetic routes both starting with 6-methylcoumarin 2 have been described to prepare 4-hydroxy-7-methyl-1-indanone 1, a constituent of cyanobacterium Nostoc commune having antibacterial activity. In the first route, methylative lactone ring opening of the coumarin 2 followed by catalytic hydrogenation of the cinnamyl double bond and subsequent PPA cyclization gives the methyl ether 5 of 1 which on demethylation gives 1 in excellent yield. Alternatively, catalytic hydrogenation of 2 followed by fusion with anhydrous AlCl3 gives high yield of 1 in just two steps.
Novel Tetrahydropyridothiophenes
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Page/Page column 63-64, (2008/12/04)
Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
Highly enantioselective 1,4-addition of arylzinc reagents to 3-arylpropenals catalyzed by a rhodium-binap complex in the presence of chlorotrimethylsilane
Tokunaga, Norihito,Hayashi, Tamio
, p. 607 - 613 (2007/10/03)
Asymmetric 1,4-addition of arylzinc chlorides to (E)-3-arylpropenals proceeded with high enantioselectivity in the presence of a rhodium/(R)-binap catalyst and chlorotrimethylsilane to give, after hydrolysis, high yields of the corresponding 3,3-diarylpro
