104126-76-3Relevant articles and documents
Non-nucleoside inhibitors of human adenosine kinase: Synthesis, molecular modeling, and biological studies
Butini, Stefania,Gemma, Sandra,Brindisi, Margherita,Borrelli, Giuseppe,Lossani, Andrea,Ponte, Anna Maria,Torti, Andrea,Maga, Giovanni,Marinelli, Luciana,La Pietra, Valeria,Fiorini, Isabella,Lamponi, Stefania,Campiani, Giuseppe,Zisterer, Daniela M.,Nathwani, Seema-Maria,Sartini, Stefania,La Motta, Concettina,Da Settimo, Federico,Novellino, Ettore,Focher, Federico
, p. 1401 - 1420 (2011/04/24)
Adenosine kinase (AK) catalyzes the phosphorylation of adenosine (Ado) to AMP by means of a kinetic mechanism in which the two substrates Ado and ATP bind the enzyme in a binary and/or ternary complex, with distinct protein conformations. Most of the desc