104208-13-1Relevant articles and documents
Synthesis and activities of a thienyl dihydropyridine series on intracellular calcium in a rat pituitary cell line (GH3/B6)
Varache-Lembege,Nuhrich,Zemb,Devaux,Vacher,Vacher,Dufy
, p. 547 - 556 (1996)
The synthesis of a thienyl dihydropyridine series according to the Hantzsch method is described. The influence of these derivatives on intracellular calcium ([Ca2+](i)) in GH3 cells was evaluated in vitro using spectrofluorimetry with indol as Ca2+ fluorescent probe. We compared their effects on [Ca2+](i) and hormone release with those of nifedipine. The most active tested compounds on [Ca2+](i) were those methylated on the 3-position of the thienyl ring (activity was about 75% of nifedipine). Interestingly, the most efficient compounds on [Ca2+](i) were also the most efficient on hormone release.
NOVEL ACTIVATORS OF GLUCOKINASE
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Page/Page column 143-145, (2009/04/25)
The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistence and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.
Functionalized tetradentate ligands for Ru-sensitized solar cells
Renouard, Thierry,Gr?tzel, Michael
, p. 8145 - 8150 (2007/10/03)
Syntheses of 6,6′-bis(1-H-benzimidazol-2-yl)-4,4′-bis(methoxycarbonyl)- 2,2′-bipyridine and a series of new quaterpyridines as functionalized tetradentate ligands is described. A molecular engineering was developed allowing different solubilities, π-systems or grafting modes.