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104266-88-8

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104266-88-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 104266-88-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,2,6 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 104266-88:
(8*1)+(7*0)+(6*4)+(5*2)+(4*6)+(3*6)+(2*8)+(1*8)=108
108 % 10 = 8
So 104266-88-8 is a valid CAS Registry Number.

104266-88-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-4-Benzyl-3-(pent-4-enoyl)oxazolidin-2-one

1.2 Other means of identification

Product number -
Other names (4S)-4-benzyl-3-(4-pentenoyl)-1,3-oxazolidin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104266-88-8 SDS

104266-88-8Relevant articles and documents

Batrachotoxin binding site antagonists

Schow,Rossignol,Lund,Schnee

, p. 181 - 186 (1997)

The preparation and SAR of a series of batrachotoxin partial structures that antagonize binding and activity of batrachotoxin are reported in this communication.

Unprecedented 8,9′-neolignans: Enantioselective synthesis of possible stereoisomers for structural determination

Takahashi, Masato,Suzuki, Noriyuki,Ishikawa, Tsutomu,Huang, Hung-Yi,Chang, Hsun-Shuo,Chen, Ih-Sheng

, p. 2585 - 2589 (2014)

(+)-Wutaienin (3) and its C-7 methyl ether (4), isolated from Zanthoxylum wutaiense, were found to be unprecedented 8,9′-neolignans containing an (S)-2-(1,1-dimethyl-1-hydroxymethyl)-7-methoxydihydrobenzofuran skeleton. Wutaienin (3) was present in the pl

PROCESS FOR PREPARATION OF BRIVARACETAM

-

Paragraph 0195, (2019/05/22)

The present invention relates to a process for the preparation of brivaracetam and salts thereof. The present invention provides process for the preparation of brivaracetam and salts thereof with high chiral purity. The present invention provides process for the preparation of brivaracetam and salts thereof wherein the amount of other stereoisomers of brivaracetam is low.

Hepatitis C replication inhibitors that target the viral NS4B protein

Miller, John F.,Chong, Pek Y.,Shotwell, J. Brad,Catalano, John G.,Tai, Vincent W.-F.,Fang, Jing,Banka, Anna L.,Roberts, Christopher D.,Youngman, Michael,Zhang, Huichang,Xiong, Zhiping,Mathis, Amanda,Pouliot, Jeffery J.,Hamatake, Robert K.,Price, Daniel J.,Seal, John W.,Stroup, Lisa L.,Creech, Katrina L.,Carballo, Luz H.,Todd, Dan,Spaltenstein, Andrew,Furst, Sylvia,Hong, Zhi,Peat, Andrew J.

supporting information, p. 2107 - 2120 (2014/04/03)

We describe the preclinical development and in vivo efficacy of a novel chemical series that inhibits hepatitis C virus replication via direct interaction with the viral nonstructural protein 4B (NS4B). Significant potency improvements were realized through isosteric modifications to our initial lead 1a. The temptation to improve antiviral activity while compromising physicochemical properties was tempered by the judicial use of ligand efficiency indices during lead optimization. In this manner, compound 1a was transformed into (+)-28a which possessed an improved antiviral profile with no increase in molecular weight and only a modest elevation in lipophilicity. Additionally, we employed a chimeric "humanized" mouse model of HCV infection to demonstrate for the first time that a small molecule with high in vitro affinity for NS4B can inhibit viral replication in vivo. This successful proof-of-concept study suggests that drugs targeting NS4B may represent a viable treatment option for curing HCV infection.

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