1042709-60-3Relevant articles and documents
General and efficient copper-catalyzed amidation of saturated C-H bonds using N-halosuccinimides as the oxidants
Liu, Xiaowei,Zhang, Yongming,Wang, Long,Fu, Hua,Jiang, Yuyang,Zhao, Yufen
, p. 6207 - 6212 (2008/12/22)
(Chemical Equation Presented) We have developed a general and efficient method for copper-catalyzed amidation of saturated C-H bonds under mild conditions, and the used substrates include benzylic reagents, the N,N-dimethylaniline derivatives, the free carboxamides, and sulfonamides. The protocol uses inexpensive and readily available CuBr/N-halosuccinimide (NBS or NCS) as the catalyst/oxidant, so it provides practical applications for synthesis of various amides via C-H activation.
