1042722-68-8

Basic information

• Product Name: C₄₃H₃₅F₂NO₃
• Synonyms: C₄₃H₃₅F₂NO₃
• CAS NO: 1042722-68-8
• Molecular Weight: 651.753
• Mol File: 1042722-68-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₃H₃₅F₂NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₃H₃₅F₂NO₃(1042722-68-8)
• EPA Substance Registry System: C₄₃H₃₅F₂NO₃(1042722-68-8)

Safety Data

• Hazardous Substances Data: 1042722-68-8(Hazardous Substances Data)

Upstream product

• 1042722-98-4 (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(trityloxy)phenyl]azetidin-2-one 

Downstream Products

• 163222-33-1 ezetemibe 

Relevant articles and documents

A METHOD OF MANUFACTURING (3R,4S)-L-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3- HYDROXYPROPYL)]-4-(4-HYDROXYPHENYL)-2-AZETIDINONE AND ITS INTERMEDIATES

A method of manufacturing (3R,4S)-l-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3- hydroxypropyl)]-4-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) of formula I, in which a protected ketone of general formula II, wherein R stands for a protective group, such as benzyloxycarbonyl, tert-butoxycarbonyl, benzhydryl or trityl, is reduced with asymmetrical borane agents in an inert organic solvent in the temperature range of -30 to +40 °C, and finally the obtained protected alcohol of general formula III, wherein R has the same meaning as above, is deprotected by the action of hydro genolytic or acidic agents in an inert organic solvent.