104292-65-1Relevant articles and documents
Iminosugar-based galactoside mimics as inhibitors of galactocerebrosidase: SAR studies and comparison with other lysosomal galactosidases
Biela-Banas, Anna,Ouladi, Farah,Front, Sophie,Gallienne, Estelle,Ikeda-Obatake, Kyoko,Asano, Naoki,Wenger, David A.,Martin, Olivier R.
, p. 2647 - 2652 (2014)
Several families of iminosugar-based galactoside mimics were designed, synthesized, and evaluated as galactocerebrosidase (GALC) inhibitors. They were also tested as inhibitors of lysosomal β- and α-galactosidases in order to find new potent and selective pharmacological chaperones for treatment of the lysosomal storage disorder, Krabbe disease. Whereas 1-C-alkyl imino-l-arabinitols are totally inactive toward the three enzymes, 1-C-alkyl imino-L-galactitols were found to be active only toward α-galactosidase A. Finally, 1-N-iminosugars provided the best results, as 4-epi-isofagomine was found to be a good inhibitor of both lysosomal β-galactosidase and GALC. Further elaboration of this structure is required to achieve selectivity between these two galactosidases.
Free-radical addition-fragmentation reactions in synthesis: A 'second generation' synthesis of (+)- pseudomonic acid C
Keck,Tafesh
, p. 5845 - 5846 (2007/10/02)
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