1042939-73-0

Basic information

• Product Name: (R)-ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-chlorophenyl)butanoate
• Synonyms: (R)-ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-chlorophenyl)butanoate
• CAS NO: 1042939-73-0
• Molecular Weight: 371.82
• Mol File: 1042939-73-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R)-ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-chlorophenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-chlorophenyl)butanoate(1042939-73-0)
• EPA Substance Registry System: (R)-ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-chlorophenyl)butanoate(1042939-73-0)

Safety Data

• Hazardous Substances Data: 1042939-73-0(Hazardous Substances Data)

Upstream product

• 145629-84-1 ethyl (2E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)but-2-enoate 
• 1679-18-1 4-Chlorophenylboronic acid 
• 2913-97-5 N-phthalimidyl-2-aminoacetaldehyde 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 

Downstream Products

• 63701-55-3 (R)-(-)-baclofen hydrochloride 

Relevant articles and documents

Enantioselective Syntheses of (-)-(R)-Rolipram, (-)-(R)-Baclofen and Other GABA Analogues via Rhodium-Catalyzed Conjugate Addition of Arylboronic Acids

Highly enantioselective syntheses of two important γ-aminobutyric acid (GABA) analogues, the antispastic drug (-)-(R)-Baclofen and the antidepressant agent (-)-(R)-Rolipram, are reported. Key-steps in both syntheses are the Rh-catalyzed asymmetric 1,4-additions of arylboronic acids to 4-aminobut-2,3-enoic acid derivatives.

Enantioselective synthesis of (-)-(R)-Baclofen and analogues via rhodium-catalysed conjugate addition of boronic acids

Highly enantioselective syntheses of the antispastic drug (-)-(R)-Baclofen and analogues have been achieved by using rhodium-catalysed asymmetric 1,4-additions of arylboronic acids to 4-amino-but-2,3-enoic acid derivatives.

Rh-catalyzed asymmetric hydrogenation of γ-phthalimido-substituted α,β-unsaturated carboxylic acid esters: An efficient enantioselective synthesis of β-aryl-γ-amino acids

(Chemical Equation Presented) A series of chiral β-aryl-γ-amino acid ester derivatives were synthesized in high enantioselectivities (93-97% ee) via the Rh-catalyzed asymmetric hydrogenation of γ-phthalimido-α, β-unsaturated carboxylic acid esters using highly modular chiral BoPhoz-type phosphine-aminophosphine ligands. The method has been applied successfully to the synthesis of several chiral pharmaceuticals including (R)-baclofen and (R)-rolipram with high enantioselectivities.